Holtkamp Hannah, Hartinger Christian G
University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland 1142, New Zealand.
University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland 1142, New Zealand.
Drug Discov Today Technol. 2015 Sep;16:16-22. doi: 10.1016/j.ddtec.2015.07.004. Epub 2015 Sep 1.
Capillary electrophoresis (CE) is a separation method based on differential migration of analytes in electric fields. The compatibility with purely aqueous separation media makes it a versatile tool in metallodrug research. Many metallodrugs undergo ligand exchange reactions that can easily be followed with this method and the information gained can even be improved by coupling the CE to advanced detectors, such as mass spectrometers. This gives the method high potential to facilitate the development of metallodrugs, especially when combined with innovative method development and experimental design.
毛细管电泳（CE）是一种基于分析物在电场中差异迁移的分离方法。与纯水性分离介质的兼容性使其成为金属药物研究中的一种通用工具。许多金属药物会发生配体交换反应，使用这种方法可以轻松跟踪这些反应，通过将毛细管电泳与先进的检测器（如质谱仪）联用，所获得的信息甚至可以得到改善。这使得该方法在促进金属药物开发方面具有很大潜力，特别是与创新的方法开发和实验设计相结合时。
