老年耳鸣患者的抗氧化治疗
Antioxidant therapy in the elderly with tinnitus.
作者信息
Polanski José Fernando, Soares Alexandra Dezani, de Mendonça Cruz Oswaldo Laércio
机构信息
Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil; Hospital de Clínicas, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.
Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.
出版信息
Braz J Otorhinolaryngol. 2016 May-Jun;82(3):269-74. doi: 10.1016/j.bjorl.2015.04.016. Epub 2015 Oct 17.
INTRODUCTION
Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is poorly controlled.
OBJECTIVE
To evaluate the effects of antioxidant therapy for tinnitus in a group of elderly patients.
METHODS
Prospective, randomized, double-blinded, placebo-controlled clinical trial. The sample consisted of 58 subjects aged 60 years or older, with a complaint of tinnitus associated with sensorineural hearing loss. These individuals completed the Tinnitus Handicap Inventory (THI) questionnaire before and after six months of therapy. The treatment regimens were: Ginkgo biloba dry extract (120mg/day), α-lipoic acid (60mg/day)+vitamin C (600mg/day), papaverine hydrochloride (100mg/day)+vitamin E (400mg/day), and placebo.
RESULTS
There was no statistically significant difference between THI by degree (p=0.441) and by score (p=0.848) before and after treatment.
CONCLUSION
There was no benefit from the use of antioxidant agents for tinnitus in this sample.
引言
治疗耳鸣已经尝试了多种方法，从认知行为疗法、声音增强到药物治疗。在这种背景下，抗氧化剂在医学的众多领域广泛使用，似乎是控制这种常常难以控制的症状的一种有前景的方法。
目的
评估抗氧化剂疗法对一组老年耳鸣患者的疗效。
方法
前瞻性、随机、双盲、安慰剂对照临床试验。样本包括58名60岁及以上的受试者，主诉耳鸣伴感音神经性听力损失。这些个体在治疗6个月前后完成了耳鸣障碍量表（THI）问卷。治疗方案为：银杏叶干提取物（120毫克/天）、α-硫辛酸（60毫克/天）+维生素C（600毫克/天）、盐酸罂粟碱（100毫克/天）+维生素E（400毫克/天）和安慰剂。
结果
治疗前后THI的程度（p = 0.441）和得分（p = 0.848）无统计学显著差异。
结论
在该样本中，使用抗氧化剂治疗耳鸣没有益处。
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