老年性聋抗氧化治疗的评估：前瞻性、安慰剂对照、双盲、随机试验。
Evaluation of antioxidant treatment in presbyacusis: prospective, placebo-controlled, double-blind, randomised trial.
作者信息
Polanski J F, Cruz O L
机构信息
Division of Otology and Neurotology, Department of Otolaryngology and Head and Neck Surgery, Federal University of São Paulo, Brazil.
出版信息
J Laryngol Otol. 2013 Feb;127(2):134-41. doi: 10.1017/S0022215112003118. Epub 2013 Jan 15.
OBJECTIVE
There are many well-known aetiological mechanisms of presbyacusis, and free radicals have been shown to play an important role. This study aimed to evaluate the effect of antioxidant agents on the hearing threshold of patients with presbyacusis.
METHODS
One hundred and twenty individuals were divided into four groups and received one of the following treatment schemes: ginkgo biloba dry extract, α-lipoic acid plus vitamin C, papaverine chlorhydrate plus vitamin E, or placebo. All participants were evaluated at recruitment and after six months, using pure tone audiometry (at isolated and average frequencies), speech recognition threshold and percentage index of speech recognition.
RESULTS
The various treatments had no effect on any of the evaluated measures of hearing, either between groups or over time.
CONCLUSION
There was no statistically significant change in the hearing threshold after treatment with any of the tested drugs, during the study period.
目的
老年性聋有许多已知的病因机制，自由基已被证明起重要作用。本研究旨在评估抗氧化剂对老年性聋患者听力阈值的影响。
方法
120名个体被分为四组，接受以下治疗方案之一：银杏叶干提取物、α-硫辛酸加维生素C、盐酸罂粟碱加维生素E或安慰剂。所有参与者在入组时和六个月后接受评估，使用纯音听力计（在孤立频率和平均频率下）、言语识别阈值和言语识别百分比指数。
结果
无论是组间还是随时间推移，各种治疗对任何评估的听力指标均无影响。
结论
在研究期间，使用任何一种受试药物治疗后，听力阈值均无统计学上的显著变化。
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