Hsu C-Y, Lin C-L, Kao C-H
Department of Medical Education and Research, Puli Christian Hospital, Puli, Taiwan.
Department of Optometry, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Int J Impot Res. 2015 Nov-Dec;27(6):233-8. doi: 10.1038/ijir.2015.25. Epub 2015 Oct 8.
This study investigated the correlation between irritable bowel syndrome (IBS) and organic erectile dysfunction (OED) and psychogenic erectile dysfunction (PED), and analyzed the influence of various comorbidities. Data were obtained from reimbursement claims of the National Health Insurance Program in Taiwan. We selected male patients aged >20 years, who were diagnosed with IBS during the 2000-2011 period as the IBS cohort. The index date for patients with IBS was the date of their first medical visit. We excluded patients with a diagnosis of OED and PED at baseline and those without information on age and sex. The IBS to non-IBS cohorts were estimated using univariable and multivariable Cox proportional hazards regression model. Adjusted hazard ratios were determined after adjusting for age and comorbidities. The Kaplan-Meier method was used to plot the cumulative incidence of OED and PED, and a log-rank test was used to compare the cohorts. A total of 15,533 IBS patients and 62,124 controls without IBS were enrolled in our study. Among the study participants, 48.2% were 49 years of age or younger. Patients with IBS were more likely to develop erectile dysfunction (ED) than those without IBS. Patients with IBS were 2.12 times more likely to develop OED and 2.38 times more likely to develop PED than the controls. There is an increased risk of both PED and OED in patients with IBS. Not only with organic but also PED should be considered when patients with IBS complain of ED.
本研究调查了肠易激综合征（IBS）与器质性勃起功能障碍（OED）和心因性勃起功能障碍（PED）之间的相关性，并分析了各种合并症的影响。数据来自台湾国民健康保险计划的报销申请。我们选择了年龄大于20岁、在2000 - 2011年期间被诊断为IBS的男性患者作为IBS队列。IBS患者的索引日期为其首次就诊日期。我们排除了基线时诊断为OED和PED的患者以及没有年龄和性别信息的患者。使用单变量和多变量Cox比例风险回归模型估计IBS队列与非IBS队列。在调整年龄和合并症后确定调整后的风险比。采用Kaplan - Meier方法绘制OED和PED的累积发病率，并使用对数秩检验比较队列。共有15533例IBS患者和62124例无IBS的对照纳入我们的研究。在研究参与者中，48.2%的患者年龄在49岁及以下。IBS患者比无IBS的患者更易发生勃起功能障碍（ED）。IBS患者发生OED的可能性是对照组的2.12倍，发生PED的可能性是对照组的2.38倍。IBS患者发生PED和OED的风险均增加。当IBS患者主诉ED时，不仅应考虑器质性因素，还应考虑心因性因素。
