CYR61/CCN1：银屑病中表皮增生和炎症的新型介质？
CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?
作者信息
Quan Taihao, Johnston Andrew, Gudjonsson Johann E, Fisher Gary J
机构信息
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
出版信息
J Invest Dermatol. 2015 Nov;135(11):2562-2564. doi: 10.1038/jid.2015.300.
Abstract
The complex pathogenesis of psoriasis is still not fully understood. The study by Sun et al. (2015) suggests that CYR61 (now named CCN1), a secreted matricellular protein, has a role in the pathogenesis of psoriasis, and thus targeting CCN1 represents a potential therapeutic strategy in its treatment.
摘要
银屑病复杂的发病机制仍未完全阐明。Sun等人（2015年）的研究表明，分泌型基质细胞蛋白CYR61（现称为CCN1）在银屑病发病机制中起作用，因此靶向CCN1可能是一种治疗银屑病的潜在策略。
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