Departments of Dermatology and Academic Wound Healing, Institute of Infection and Immunity, Cardiff University and University Hospital of Wales, Heath Park, Cardiff, UK.
Departments of Dermatology and Academic Wound Healing, Institute of Infection and Immunity, Cardiff University and University Hospital of Wales, Heath Park, Cardiff, UK.
J Invest Dermatol. 2015 Nov;135(11):2565-2567. doi: 10.1038/jid.2015.293.
Herpes simplex virus (HSV-1) is a major cause of viral skin infection in humans. Klenner and colleagues now show that the epidermal receptor activator of NFκB ligand (RANKL) is critical for the induction of anti-viral CD8(+) effector T cells (CTL) during cutaneous HSV-1 infection. Activation via RANKL prevents Langerhans cell apoptosis, thus leading to enhanced antigen transport to regional lymph nodes, increasing the CTL-priming capacity of lymph node dendritic cells.
单纯疱疹病毒 1 型（HSV-1）是人类病毒性皮肤感染的主要原因。Klenner 及其同事现在表明，表皮核因子-κB 配体（RANKL）受体对于诱导皮肤单纯疱疹病毒 1 感染期间的抗病毒 CD8(+)效应 T 细胞（CTL）至关重要。通过 RANKL 的激活可防止朗格汉斯细胞凋亡，从而导致增强的抗原向区域淋巴结的转运，增加淋巴结树突状细胞的 CTL 启动能力。
