一项使用基于体素分析和感兴趣区域方法的扩散张量成像研究，以分析首发、未接受过治疗的重度抑郁症患者的白质异常。
A Diffusion Tensor Imaging Study Using a Voxel-Based Analysis, Region-of-Interest Method to Analyze White Matter Abnormalities in First-Episode, Treatment-Naïve Major Depressive Disorder.
作者信息
Srivastava Shruti, Bhatia Manjeet S, Bhargava S K, Kumari Rima, Chandra Sushil
机构信息
From the Depts. of Psychiatry (SS, MSB) and Radiology (SKB), University College of Medical Sciences and Guru Tegh Bahadur Hospital, Dilshad Garden, Delhi, India; the Dept. of Neuroradiology, Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi, India (RK); and the BioMedical Dept., Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, New Delhi, India (SC).
出版信息
J Neuropsychiatry Clin Neurosci. 2016 Spring;28(2):131-7. doi: 10.1176/appi.neuropsych.15050120. Epub 2015 Nov 9.
This study used fractional anisotropy (FA), a measure of diffusion tensor imaging, to analyze white matter abnormalities in 15 first-episode treatment-naïve patients with major depressive disorder (MDD) and 15 controls matched for age. An automated voxel-based analysis and a region-of-interest (ROI) method with 3T magnetic resonance imaging were used. Compared with controls, FA values were lower in the left superior longitudinal fasciculus, the left prefrontal cortex, and the left parietal region in patients with MDD. In addition, the ROI method revealed significantly lower FA values in the right hippocampus. Voxel-based analysis, a faster technique, complements the ROI method, which highlights FA values as potential biomarkers in early MDD.
本研究采用分数各向异性（FA）这一扩散张量成像指标，对15例首次发作、未接受过治疗的重度抑郁症（MDD）患者及15名年龄匹配的对照者的白质异常进行分析。使用基于体素的自动分析方法以及3T磁共振成像的感兴趣区域（ROI）方法。与对照组相比，MDD患者左侧上纵束、左侧前额叶皮质及左侧顶叶区域的FA值较低。此外，ROI方法显示右侧海马体的FA值显著更低。基于体素的分析是一种更快的技术，可补充ROI方法，后者将FA值作为早期MDD的潜在生物标志物突显出来。
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