McKusick-Nathans Institute of Genetic Medicine; Institute for Cell Engineering; and Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mol Aspects Med. 2016 Feb-Mar;47-48:15-23. doi: 10.1016/j.mam.2015.09.004. Epub 2015 Nov 5.
Stem cells are characterized by the capacity for both self-renewal and generation of all other cell types (pluripotency) or differentiated cells within a particular lineage (multipotency). Stem cells are often localized to hypoxic niches within tissues and hypoxia inducible factors (HIFs) play key roles in the maintenance of pluripotent and multipotent stem cells, as well as cancer stem cells, which are also known as tumor-initiating cells. HIF inhibitors target cancer stem cells and improve the responses to angiogenesis inhibitors and cytotoxic chemotherapy in mouse models of breast cancer.
干细胞的特征是具有自我更新和产生所有其他细胞类型（多能性）或特定谱系内的分化细胞（多能性）的能力。干细胞通常定位于组织中的低氧龛内，缺氧诱导因子 (HIF) 在维持多能性和多能性干细胞以及癌症干细胞（也称为肿瘤起始细胞）中发挥关键作用。HIF 抑制剂靶向癌症干细胞，并改善乳腺癌小鼠模型中对血管生成抑制剂和细胞毒性化疗的反应。
