Chang Joe H, Gehrke Christopher, Prabhakar Ramachandran, Gill Suki, Wada Morikatsu, Lim Joon Daryl, Khoo Vincent
Radiation Oncology Centre, Austin Health, Heidelberg, Victoria, Australia; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; University of Melbourne, Victoria, Australia.
Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Phys Med. 2016 Jan;32(1):248-54. doi: 10.1016/j.ejmp.2015.10.091. Epub 2015 Nov 6.
Radiotherapy plan evaluation is currently performed by assessing physical parameters, which has many limitations. Biological modelling can potentially allow plan evaluation that is more reflective of clinical outcomes, however further research is required into this field before it can be used clinically.
A simple program, RADBIOMOD, has been developed using Visual Basic for Applications (VBA) for Microsoft Excel that incorporates multiple different biological models for radiotherapy plan evaluation, including modified Poisson tumour control probability (TCP), modified Zaider-Minerbo TCP, Lyman-Kutcher-Burman normal tissue complication probability (NTCP), equivalent uniform dose (EUD), EUD-based TCP, EUD-based NTCP, and uncomplicated tumour control probability (UTCP). RADBIOMOD was compared to existing biological modelling calculators for 15 sample cases.
Comparing RADBIOMOD to the existing biological modelling calculators, all models tested had mean absolute errors and root mean square errors less than 1%.
RADBIOMOD produces results that are non-significantly different from existing biological modelling calculators for the models tested. It is hoped that this freely available, user-friendly program will aid future research into biological modelling.
目前放疗计划评估是通过评估物理参数来进行的，这存在许多局限性。生物建模有可能实现更能反映临床结果的计划评估，然而在其能够用于临床之前，该领域还需要进一步研究。
使用针对Microsoft Excel的应用程序可视化Basic（VBA）开发了一个简单程序RADBIOMOD，该程序纳入了多种不同的用于放疗计划评估的生物模型，包括修正的泊松肿瘤控制概率（TCP）、修正的扎伊德 - 米内尔博TCP、莱曼 - 库彻 - 伯曼正常组织并发症概率（NTCP）、等效均匀剂量（EUD）、基于EUD的TCP、基于EUD的NTCP以及无并发症肿瘤控制概率（UTCP）。将RADBIOMOD与现有的生物建模计算器针对15个样本病例进行了比较。
将RADBIOMOD与现有的生物建模计算器进行比较，所有测试模型的平均绝对误差和均方根误差均小于1%。
对于所测试的模型，RADBIOMOD产生的结果与现有的生物建模计算器相比无显著差异。希望这个免费提供、用户友好的程序将有助于未来生物建模的研究。
