一例卡马西平致死性摄入病例中卡马西平-10,11-环氧化物/卡马西平比值显著升高
Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion.
作者信息
Russell Jason L, Spiller Henry A, Baker Daniel D
机构信息
The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA ; Nationwide Children's Hospital, Columbus, OH 43205, USA.
Nationwide Children's Hospital, Columbus, OH 43205, USA ; Central Ohio Poison Center, Columbus, OH 43205, USA.
出版信息
Case Rep Med. 2015;2015:369707. doi: 10.1155/2015/369707. Epub 2015 Oct 13.
Abstract
Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent. We report a case of fatal carbamazepine overdose in which the epoxide metabolite concentration was found to be 450% higher than the parent compound, suggesting a potential role for metabolite quantification in severe toxicity.
摘要
卡马西平是一种广泛使用的抗惊厥药。其代谢产物卡马西平-10,11-环氧化物已被发现具有类似的抗惊厥和神经毒性特性。虽然母体与代谢产物浓度的比例差异很大，但在治疗剂量下，环氧化物浓度通常约为母体的20%。我们报告一例卡马西平过量致死病例，其中发现环氧化物代谢产物浓度比母体化合物高450%，这表明代谢产物定量在严重毒性中可能发挥作用。
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