基质金属蛋白酶-12（MMP-12）-82A/G多态性与癌症风险的关联：一项荟萃分析。
Association between MMP-12-82A/G polymorphism and cancer risk: a meta-analysis.
作者信息
Liu Luliang, Sun Jinhuan, Li Guolin, Gu Boyu, Wang Xiaolong, Chi Huirong, Guo Fulin
机构信息
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
Department of Periodontology, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
出版信息
Int J Clin Exp Med. 2015 Aug 15;8(8):11896-904. eCollection 2015.
BACKGROUND
Numerous studies have focused on the association between MMP-12-82A>G polymorphism and cancer risk, but produced inconsistent results. Therefore, we performed a meta-analysis of case-control study to evaluate the association of MMP-12-82A>G polymorphism and cancer risk.
METHODS
A systematic literature search was conducted among PubMed, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI) and Wangfang databases updated on May 1st, 2015. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of association between this polymorphism and cancer risk.
RESULTS
A total of seventeen case-control studies with 7,450 cases and 7,348 controls were identified and analyzed. Overall, there was no statistically significant association between MMP-12-82A>G polymorphism and increased risk of cancer under all genetic models. Subgroup analysis by ethnicity observed that there is no strong relationship between MMP-12-82A>G polymorphism and cancer risk among Asian and European populations. Furthermore, stratified analysis based on the source of control revealed no statistically significant association between MMP-12-82A>G polymorphism and cancer risk either in hospital-based or population-based studies. However, when we stratified analysis based on cancer type, significant association was found in ovarian cancer, but not in other types of cancer.
CONCLUSION
This meta-analysis suggests that MMP-12-82A>G polymorphism is not significantly associated with overall cancer risk. However, MMP-12-82A>G polymorphism may increase the susceptibility to ovarian cancer.
背景
众多研究聚焦于基质金属蛋白酶-12（MMP-12）-82A>G多态性与癌症风险之间的关联，但结果并不一致。因此，我们进行了一项病例对照研究的荟萃分析，以评估MMP-12-82A>G多态性与癌症风险的关联。
方法
在PubMed、科学网、科学Direct、中国知网（CNKI）和万方数据库中对截至2015年5月1日更新的文献进行系统检索。采用粗比值比（OR）及95%置信区间（CI）评估该多态性与癌症风险之间关联的强度。
结果
共纳入并分析了17项病例对照研究，涉及7450例病例和7348例对照。总体而言，在所有遗传模型下，MMP-12-82A>G多态性与癌症风险增加之间无统计学显著关联。按种族进行亚组分析发现，在亚洲和欧洲人群中，MMP-12-82A>G多态性与癌症风险之间无密切关系。此外，基于对照来源的分层分析显示，在基于医院和基于人群的研究中，MMP-12-82A>G多态性与癌症风险之间均无统计学显著关联。然而，当我们按癌症类型进行分层分析时，发现MMP-12-82A>G多态性与卵巢癌存在显著关联，而与其他类型癌症无关联。
结论
这项荟萃分析表明，MMP-12-82A>G多态性与总体癌症风险无显著关联。然而，MMP-12-82A>G多态性可能会增加患卵巢癌的易感性。
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