基质金属蛋白酶-12 和 -13 的基因多态性与瑞典患者结直肠癌的关系。

Gene polymorphism of matrix metalloproteinase-12 and -13 and association with colorectal cancer in Swedish patients.

机构信息

Department of Natural Science and Biomedicine, University College of Health Sciences, Jönköping, Sweden.

出版信息

Anticancer Res. 2013 Aug;33(8):3247-50.

Abstract

BACKGROUND

It has been widely reported that matrix metalloproteinases (MMPs) have fundamental roles in pathological processes in cancer through degradation of basal membranes and extracellular matrix. For MMP12 and MMP13, a functional single nucleotide polymorphism (SNP) has been detected -82A →G (rs2276109) and -77A →G (rs2252070), respectively. These SNPs are suggested to have an influence on different diseases. The present study evaluated the association between these SNPs in patients with colorectal cancer (CRC) patients and healthy controls.

PATIENTS AND METHODS

Using the TaqMan system, these SNPs were screened in 385 patients with CRC and 619 controls.

RESULTS

No significant difference in genotype distribution or in allelic frequencies was found between the two groups. However, we showed that the AA MMP-12 genotype is connected with a higher risk of disseminated CRC (Odds Ratio=1.77; 95% Confidence Interval=1.11-2.81, p=0.018).

CONCLUSION

The results of this study suggest that the -82A →G (rs2276109) polymorphism of the MMP12 gene reflects clinical outcome of patients with CRC.

摘要

背景

已有大量报道表明，基质金属蛋白酶（MMPs）通过降解基底膜和细胞外基质，在癌症的病理过程中发挥着重要作用。对于 MMP12 和 MMP13，分别检测到一个功能性单核苷酸多态性（SNP）-82A →G（rs2276109）和-77A →G（rs2252070）。这些 SNP 被认为对不同的疾病有影响。本研究评估了这些 SNP 在结直肠癌（CRC）患者和健康对照组中的相关性。