中国天津地区不孕症患者血清生殖系统相关自身抗体分析
Analysis of the serum reproductive system related autoantibodies of infertility patients in Tianjin region of China.
作者信息
Huo Yan, Xu Yanying, Wang Jianmei, Wang Fang, Liu Yu, Zhang Yujuan, Zhang Bumei
机构信息
Department of Family Planning, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
Department of Gynecology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
出版信息
Int J Clin Exp Med. 2015 Aug 15;8(8):14048-53. eCollection 2015.
OBJECT
Reproductive system related autoantibodies have been proposed to be associated with natural infertility. However, large scale systematic analysis of these of antibodies has not been conducted. The aim of this study is to analyze the positive rate of antisperm antibody (ASAb), anti-endometrium antibody (EMAb), anti-ovary antibody (AOAb), anti-zona pellucida antibody (AZP) and anticardiolipin antibody (ACA) in infertility patients in Tianjin region of China.
METHODS
1305 male and 1711 female primary infertility patients and 1100 female secondary infertility patients were included in this study, as well as 627 healthy female controls. The above autoantibodies were tested and the positive rates in each group were calculated.
RESULTS
the positive rate of ASAb were significantly higher in primary infertility female than that in male, further analysis revealed that primary infertility population all exhibit significant higher positive rate of EMAb, AOAb, AZP and ACA compared with control group. Furthermore, the positive rates of all the antibodies in primary infertility female were significantly higher than those in secondary infertility female.
CONCLUSIONS
Our study thus indicates that these autoantibodies might be associated with immunological related primary infertility and may have clinical significance in its diagnosis and treatment.
目的
生殖系统相关自身抗体被认为与自然不孕症有关。然而，尚未对这些抗体进行大规模系统分析。本研究旨在分析中国天津地区不孕症患者中抗精子抗体（ASAb）、抗子宫内膜抗体（EMAb）、抗卵巢抗体（AOAb）、抗透明带抗体（AZP）和抗心磷脂抗体（ACA）的阳性率。
方法
本研究纳入1305例男性和1711例女性原发性不孕症患者、1100例女性继发性不孕症患者以及627例健康女性对照。检测上述自身抗体并计算每组的阳性率。
结果
原发性不孕症女性中ASAb的阳性率显著高于男性，进一步分析显示，与对照组相比，原发性不孕症人群中EMAb、AOAb、AZP和ACA的阳性率均显著更高。此外，原发性不孕症女性中所有抗体的阳性率均显著高于继发性不孕症女性。
结论
因此，我们的研究表明，这些自身抗体可能与免疫相关的原发性不孕症有关，并且可能在其诊断和治疗中具有临床意义。
Zotero 插件