作为胶质母细胞瘤治疗靶点的转运蛋白18 kDa（TSPO）
TSPO as a target for glioblastoma therapeutics.
作者信息
Werry Eryn L, Barron Melissa L, Kassiou Michael
机构信息
Faculty of Health Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
Faculty of Health Sciences, The University of Sydney, Sydney, NSW 2006, Australia School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
出版信息
Biochem Soc Trans. 2015 Aug;43(4):531-6. doi: 10.1042/BST20150015. Epub 2015 Aug 3.
The translocator protein (TSPO) is an 18-kDa five-transmembrane protein, which is primarily found in the outer mitochondrial membrane. Levels of this protein are up-regulated in the most aggressive and common glioma, glioblastoma multiforme (GM). Levels of TSPO also correlate with GM clinical outcome, suggesting that TSPO may be a novel GM diagnostic imaging agent. Therapeutically, targeting the TSPO may provide a mechanism to abrogate the apoptotic-resistant, invasive and aggressive nature of GM and may also provide a way of targeting other anti-cancer treatments to GM sites. This review highlights recent progress in research on TSPO-based diagnostic imaging and therapeutics for GM.
转位蛋白（TSPO）是一种18 kDa的五跨膜蛋白，主要存在于线粒体外膜。在最具侵袭性且常见的胶质瘤——多形性胶质母细胞瘤（GM）中，这种蛋白的水平会上调。TSPO的水平还与GM的临床结果相关，这表明TSPO可能是一种新型的GM诊断成像剂。在治疗方面，靶向TSPO可能提供一种机制来消除GM的抗凋亡、侵袭性和攻击性特性，还可能提供一种将其他抗癌治疗靶向GM部位的方法。本综述重点介绍了基于TSPO的GM诊断成像和治疗研究的最新进展。
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