减重手术对中国肥胖成年人糖代谢、炎性细胞因子及血清抗酒石酸酸性磷酸酶5a的影响
Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults.
作者信息
Shih Kuang-Chung, Janckila Anthony J, Lee Wei-Jei, Chou Yu-Ching, Huang Chun-Jui, Kwok Ching-Fai, Ho Low-Tone, Chao Tsu-Yi
机构信息
Division of Endocrinology and Metabolism, Department of Medicine, Taipei-Veteran General Hospital, Taipei, Taiwan; Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Special Hematology Laboratory, Department of Hematology, Veterans Affairs Medical Center, Louisville, KY, USA; Department of Microbiology and Immunology, University of Louisville, School of Medicine, Louisville, KY, USA.
出版信息
Clin Chim Acta. 2016 Jan 30;453:197-202. doi: 10.1016/j.cca.2015.11.004. Epub 2015 Nov 10.
BACKGROUND
We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults.
METHODS
Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12months postoperatively.
RESULTS
Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12months in non-DM group, while improving significantly at 6 and 12months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12months in non-DM group and 12months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12months postoperatively without significant changes in CRP and IL-6.
CONCLUSION
Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.
背景
我们确定了减肥手术对中国重度肥胖成年人血清抗酒石酸酸性磷酸酶5a（TRACP 5a）、炎性细胞因子和葡萄糖稳态的影响。
方法
招募接受减肥手术的重度肥胖成年人。在基线以及术后3、6和12个月测量人体测量学指标、胰岛素抵抗（IR）、炎症标志物和血清TRACP 5a。
结果
分析了93例患者的数据，包括69例非糖尿病患者（非糖尿病组）和24例糖尿病患者（糖尿病组）。两组术后3个月人体测量学指标均显著下降；非糖尿病组在术后3、6和12个月低密度脂蛋白胆固醇明显下降，而糖尿病组在术后6和12个月显著改善。非糖尿病组在术后3、6和12个月以及糖尿病组在术后12个月胰岛素抵抗稳态模型评估（HOMA-IR）显著改善。在糖尿病组，术后3个月C反应蛋白（CRP）显著下降，术后6个月炎性标志物白细胞介素-6（IL-6）和TRACP 5a改善；在非糖尿病组，术后12个月血清TRACP 5a明显下降，CRP和IL-6无显著变化。
结论
减肥手术减轻体重可降低中国重度肥胖成年人的人体测量学指标、IR、血脂和炎症标志物。
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