Shu Yang, Zhu Liucun, Yuan Fei, Kong Xiangyin, Huang Tao, Cai Yu-Dong
School of Life Sciences, Shanghai University, Shanghai 200444, P.R. China.
Comb Chem High Throughput Screen. 2016;19(2):100-8. doi: 10.2174/1386207319666151110123345.
Lung cancer, characterized by uncontrolled cell growth in tissues of the lung, is one of the leading causes of cancer mortality worldwide. Many etiologic factors for lung cancer tumorigenesis have been identified to date, such as smoking and exposure to radon, cooking fumes and asbestos. Atmospheric pollution has become increasingly heavy in China in recent years. Accordingly, greater numbers of people are paying attention to the air quality around them. PM2.5 (particulate matter with a diameter of 2.5 micrometers or less), which is one of the most important indicators for measuring air quality, can penetrate and be retained in lung tissue. It is believed that PM2.5 may represent a new type of etiological factor for lung cancer. This study constitutes the analysis of the association between PM2.5 and lung cancer. Genes related to small/nonsmall cell lung cancer were evaluated by assigning scores to measure the impact caused by PM2.5. Analyses of small/nonsmall cell lung cancer genes with high scores revealed that it is theoretically possible that PM2.5 is an etiologic factor for lung cancer. Our results provided new insights of the relationship between lung cancers and air pollution.
肺癌以肺部组织中细胞的无节制生长为特征，是全球癌症死亡的主要原因之一。迄今为止，已确定了许多导致肺癌发生的病因，如吸烟以及接触氡、烹饪油烟和石棉。近年来，中国的大气污染日益严重。因此，越来越多的人开始关注周围的空气质量。PM2.5（直径等于或小于2.5微米的颗粒物）是衡量空气质量的最重要指标之一，它能够穿透并滞留在肺组织中。人们认为，PM2.5可能是一种新型的肺癌致病因素。本研究对PM2.5与肺癌之间的关联进行了分析。通过打分来评估与小/非小细胞肺癌相关的基因，以衡量PM2.5造成的影响。对高分的小/非小细胞肺癌基因进行分析后发现，PM2.5在理论上有可能是肺癌的致病因素。我们的研究结果为肺癌与空气污染之间的关系提供了新的见解。
