Chertow Glenn M, Beddhu Srinivasan, Lewis Julia B, Toto Robert D, Cheung Alfred K
Division of Nephrology, Department of Medicine, Stanford University, Stanford, California;
Division of Nephrology, Internal Medicine School of Medicine, University of Utah, Salt Lake City, Utah;
J Am Soc Nephrol. 2016 Jan;27(1):40-3. doi: 10.1681/ASN.2015101125. Epub 2015 Nov 9.
In this manuscript, nephrologist-investigators from one of five Clinical Center Networks of the Systolic Blood Pressure Intervention Trial (SPRINT) provide background information and context on the intensity of anti-hypertensive therapy in conjunction with the release of detailed results from SPRINT's primary analysis. The authors highlight published evidence on the safety and efficacy of differing intensities of anti-hypertensive therapy in mild to moderate CKD, where SPRINT will help to inform practice, as well as where gaps in evidence will remain. The authors also challenge the nephrology community to renew its attention and efforts on hypertension clinical care and research.
在本手稿中,收缩压干预试验(SPRINT)五个临床中心网络之一的肾脏病学研究人员,结合SPRINT初步分析的详细结果发布,提供了关于降压治疗强度的背景信息和相关情况。作者强调了已发表的关于不同强度降压治疗在轻度至中度慢性肾脏病中的安全性和有效性的证据,SPRINT将有助于为实践提供参考,同时也指出了证据方面仍存在的差距。作者还呼吁肾脏病学界重新关注并加大高血压临床护理和研究方面的力度。