Dervişoğulları Mehmet Serdar, Totan Yüksel, Yüce Aslıhan, Kulak Ali Ender
a Ophthalmology Department, Koru Sincan Hospital , Ankara , Turkey and.
b Ophthalmology Department, Turgut Ozal University , Ankara , Turkey.
Cutan Ocul Toxicol. 2016 Dec;35(4):281-6. doi: 10.3109/15569527.2015.1104330. Epub 2015 Nov 10.
To explore ocular changes in healthy people after caffeine consumption.
This prospective observational study was carried out with students of the Turgut Özal University Medical Faculty from May 15 to 15 December 2014. Enrolled in the study were 17 healthy subjects (n = 17 eyes), with a median age of 24 (IQR 1), ranging between 21 and 26 years. The control group (6 females, 11 males) aged between 23 and 28 (median 25 years [IQR 4.75]). For study, one eye from each participant was randomly selected. To obviate the effect of diurnal variations, tests were performed at the same time of the day (10:00 a.m.-12:00 p.m.). Each subject was given an ophthalmologic examination before the study to exclude those with undiagnosed ocular disease. Version 6.0 Cirrus high-definition optical coherence tomography (HD-OCT) (Carl Zeiss Meditec, Dublin, CA) was used to measure CT at the fovea, and 1500 μm nasal and 1500 μm temporal to the fovea. After baseline OCT measurements, participants were asked to have 200 mg oral caffeine intake or a placebo capsule (200 mg lactose powder). Two further OCT measurements were applied at the first and fourth hours of caffeine intake. All participants also had intraocular pressure (IOP) and ocular pulse amplitude (OPA) measurements recorded before, first and fourth hours of caffeine intake. IOP and OPA were measured using the dynamic contour tonometry (DCT) (Swiss Micro Technology AG, Port, Switzerland).
The groups showed no significant difference by means of age, gender, spherical refraction and axial length (p > 0.05). Baseline choroidal thickness measurements of the study and control group showed no significant difference. Oral caffeine intake caused a significant reduction in choroidal thickness compared with baseline, at all three measurement points, (p < 0.05). There were no significant changes in IOP and OPA measurements compared with the baseline values (p > 0.05). The choroidal thickness still continued to decrease for at least 4 h following caffeine intake; whereas, the difference between 1 and 4 h was not statistically significant (p > 0.05). However, choroidal thicknesses, IOP and OPA values of the control group revealed no significant difference at all points when comparing measurements at baseline with 1 and 4 h after placebo intake (p > 0.05).
We found no significant change in IOP and OPA following oral 200 mg caffeine intake, while CT significantly decreased, for at least 4 h.
探讨健康人摄入咖啡因后的眼部变化。
本前瞻性观察性研究于2014年5月15日至12月15日在图尔古特·厄扎尔大学医学院的学生中进行。纳入研究的有17名健康受试者（n = 17只眼），中位年龄为24岁（四分位间距1），年龄在21至26岁之间。对照组（6名女性，11名男性）年龄在23至28岁之间（中位年龄25岁[四分位间距4.75]）。为进行研究，从每位参与者中随机选择一只眼睛。为消除昼夜变化的影响，测试在一天中的同一时间（上午10:00 - 12:00）进行。在研究前对每位受试者进行眼科检查，以排除未诊断出眼部疾病的人。使用版本6.0的Cirrus高清光学相干断层扫描（HD - OCT）（卡尔·蔡司医疗技术公司，加利福尼亚州都柏林）测量黄斑中心凹、黄斑中心凹鼻侧1500μm和颞侧1500μm处的脉络膜厚度。在进行基线OCT测量后，让参与者口服200mg咖啡因或一粒安慰剂胶囊（200mg乳糖粉）。在摄入咖啡因后的第一小时和第四小时再进行两次OCT测量。所有参与者在摄入咖啡因前、第一小时和第四小时还记录了眼压（IOP）和眼脉搏振幅（OPA）。使用动态轮廓眼压计（DCT）（瑞士微技术公司，瑞士波特）测量IOP和OPA。
两组在年龄、性别、球镜度数和眼轴长度方面无显著差异（p > 0.05）。研究组和对照组的基线脉络膜厚度测量结果无显著差异。与基线相比，口服咖啡因后在所有三个测量点的脉络膜厚度均显著降低（p < 0.05）。与基线值相比，IOP和OPA测量值无显著变化（p > 0.05）。摄入咖啡因后脉络膜厚度至少在4小时内持续下降；然而，1小时和4小时之间的差异无统计学意义（p > 0.05）。但是，在比较安慰剂摄入后1小时和4小时与基线的测量值时，对照组的脉络膜厚度、IOP和OPA值在所有时间点均无显著差异（p > 0.05）。
我们发现口服200mg咖啡因后，IOP和OPA无显著变化，而脉络膜厚度显著降低，至少持续4小时。
Zotero 插件