Ozturk Karabulut Gamze, Fazil Korhan, Ozturker Can, Gunaydin Zehra Karaağaç, Altan Cigdem, İnal Asli, Taskapili Muhittin, Kaynak Pelin
Ophthalmic Plastic and Reconstructive Surgery Department, University of Health Sciences, Istanbul Beyoglu Eye Research and Training Hospital , Istanbul , Turkey.
Orbit. 2019 Oct;38(5):347-352. doi: 10.1080/01676830.2018.1533568. Epub 2018 Oct 18.
: The aim of this study was to evaluate whether orbital changes induced by thyroid eye disease affect the ocular pulse amplitude and choroidal perfusion. : A total of 38 eyes of 38 patients with thyroid eye disease (Group 1) and 38 eyes of 38 control individuals (Group 2) with normal intraocular pressure were enrolled in this study. Thyroid eye disease activity was defined using clinical activity score. Intraocular pressure measurement with Goldmann applanation tonometer, axial length, central corneal thickness, Hertel exophthalmometry and systolic and diastolic blood pressure measurements were taken from each patient. Ocular pulse amplitude and intraocular pressure were measured using dynamic contour tonometry. Choroidal thickness was measured by enhanced depth imaging-optical coherence tomography at subfoveal, nasal and temporal 1000 μm area. : Intraocular pressures measured with Goldmann applanation tonometer and dynamic contour tonometry and mean ocular pulse amplitude were not statistically different between groups. However mean choroidal thicknesses were significantly lower when compared to control group. Ocular pulse amplitude and intraocular pressure measurement with dynamic contour tonometry did not change significantly with the increase in clinical activity score. There was not statistically significant correlation between ocular pulse amplitude and choroidal thicknesses in patients with thyroid eye disease. : Ocular pulse amplitude and choroidal perfusion were not found to change with orbital involvement in thyroid eye disease and with disease activity, especially in patients with normal intraocular pressure. Although choroidal thickness was thinner than control group, choroidal perfusion did not change as a compensatory mechanism for maintaining ocular homeostasis.
本研究的目的是评估甲状腺眼病引起的眼眶变化是否会影响眼脉搏振幅和脉络膜灌注。本研究纳入了38例甲状腺眼病患者的38只眼（第1组）和38名眼压正常的对照个体的38只眼（第2组）。使用临床活动评分来定义甲状腺眼病的活动度。对每位患者进行Goldmann压平眼压计测量眼压、眼轴长度、中央角膜厚度、Hertel眼球突出度测量以及收缩压和舒张压测量。使用动态轮廓眼压计测量眼脉搏振幅和眼压。通过增强深度成像光学相干断层扫描在黄斑中心凹下、鼻侧和颞侧1000μm区域测量脉络膜厚度。使用Goldmann压平眼压计和动态轮廓眼压计测量的眼压以及平均眼脉搏振幅在两组之间无统计学差异。然而，与对照组相比，平均脉络膜厚度显著更低。随着临床活动评分的增加，使用动态轮廓眼压计测量的眼脉搏振幅和眼压没有显著变化。甲状腺眼病患者的眼脉搏振幅与脉络膜厚度之间没有统计学上的显著相关性。在甲状腺眼病中，尤其是眼压正常的患者，未发现眼脉搏振幅和脉络膜灌注随眼眶受累情况和疾病活动度而改变。尽管脉络膜厚度比对照组薄，但脉络膜灌注并未作为维持眼内稳态的代偿机制而发生改变。
