Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan.
Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):27. doi: 10.1167/iovs.62.3.27.
The effects of coffee intake on the ratio of stromal and luminal components in the choroid and the underlying mechanism remain unclear. This prospective cross-sectional study aimed to explore how coffee intake affects the choroidal component ratio and circulation.
Forty-nine right eyes of healthy adult volunteers were evaluated as the coffee intake group. Thirty-two right eyes of healthy volunteers served as the control group. The participants consumed 185 mL of coffee or water, respectively, and the systemic hemodynamics, enhanced-depth imaging optical coherence tomographic (EDI-OCT) images, and foveal mean blur rate (MBR), an indicator of blood flow velocity, were recorded at baseline and after coffee or water intake. The EDI-OCT images were binarized using ImageJ software, and subfoveal choroidal thickness (SCT) and whole, luminal, and stromal choroidal areas were calculated.
In the coffee intake group, significant decreases in SCT and luminal area peaked at 60 minutes after intake (both P < 0.001), whereas a significant increase in MBR peaked at 30 minutes (P < 0.001). No significant stromal area fluctuations were observed. SCT and luminal area fluctuations exhibited a significant positive correlation (r = 0.978, P < 0.001). Significant negative correlations of luminal area fluctuations with MBR fluctuations were observed by stepwise regression analysis (r = -0.220, P < 0.001). The control group exhibited no significant fluctuations.
Coffee-induced choroidal thinning may result mainly from a reduction in the choroidal vessel lumen, and this vessel lumen reduction correlated with an increased choroidal blood flow velocity after coffee intake. These coffee-induced changes in choroidal component ratio and circulation should be considered when evaluating choroids.
咖啡摄入对脉络膜基质和管腔成分比例的影响及其潜在机制尚不清楚。本前瞻性横断面研究旨在探讨咖啡摄入如何影响脉络膜成分比例和循环。
评估 49 名健康成年志愿者的 49 只右眼为咖啡摄入组，32 名健康志愿者的 32 只右眼为对照组。两组分别饮用 185 毫升咖啡或水，分别于基线和咖啡或水摄入后记录系统血流动力学、增强深度成像光学相干断层扫描（EDI-OCT）图像和黄斑中心凹平均模糊率（MBR），以指示血流速度。使用 ImageJ 软件对 EDI-OCT 图像进行二值化，计算黄斑中心凹下脉络膜厚度（SCT）和全层、管腔和基质脉络膜面积。
在咖啡摄入组中，SCT 和管腔面积在摄入后 60 分钟显著下降（均 P < 0.001），而 MBR 在 30 分钟时显著升高（P < 0.001）。未观察到基质面积波动。SCT 和管腔面积波动呈显著正相关（r = 0.978，P < 0.001）。逐步回归分析显示，管腔面积波动与 MBR 波动呈显著负相关（r = -0.220，P < 0.001）。对照组无明显波动。
咖啡引起的脉络膜变薄可能主要是由于脉络膜血管管腔缩小引起的，这种管腔缩小与咖啡摄入后脉络膜血流速度增加相关。在评估脉络膜时，应考虑这些由咖啡引起的脉络膜成分比例和循环变化。
