Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Epidemiology and Statistics, Institute of Basic Medical Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Invest Ophthalmol Vis Sci. 2022 Oct 3;63(11):27. doi: 10.1167/iovs.63.11.27.
To compare the difference in anterior segment biometrics derived from anterior segment optical coherence tomography (AS-OCT) between treatment-naïve acromegaly patients and normal controls and evaluate the correlations between above biometrics and insulin-like growth factor 1 (IGF-1) and growth hormone (GH) levels.
Sixty eyes of 30 acromegaly patients and 60 eyes of 30 normal controls were included in this case-control study. Central corneal thickness, pupil diameter, iris thickness (IT), iris curvature (IC), anterior chamber depth (ACD), anterior chamber width, lens vault (LV), angle open distance (AOD) 500, AOD750, and trabecular iris space area (TISA) 500 and TISA750 were measured by AS-OCT. General linear regression models were constructed to evaluate the independent endocrine factors affecting iris morphology and anterior chamber angle (ACA) width.
The acromegaly patients had an evenly thicker iris (P < 0.001), a smaller IC (P < 0.05), a smaller LV (P = 0.040) and significantly larger AOD500, AOD750, TISA500 and TISA750 (P < 0.001). There was a positive correlation between the serum GH level and ACD in the acromegaly patients (P = 0.031). Linear regression models showed the lower LV and smaller IC were independent influencing factors of the increase in the AOD500, AOD750, and TISA750 and nasal TISA500. Serum IGF-1 was an independent factor for the increase in pupil diameter (β = 0.002, P = 0.031) and both the average nasal (β = 6.78110-5, P = 0.049) and temporal (β = 7.73610-5, P = 0.045) IT values and for the decrease in temporal IC (β < 0.001, P = 0.037). GH was an independent factor for the increase in temporal AOD750 (β = 0.001, P = 0.030) and temporal TISA750 (β = 0.002, P = 0.016).
Patients with acromegaly have a thicker IT, smaller IC, and lower LV with a wider ACA than normal controls. Serum GH is independently correlated with the temporal ACA width, whereas serum IGF-1 is independently correlated with IT, pupil diameter, and IC.
比较未经治疗的肢端肥大症患者和正常对照者的前节光学相干断层扫描（AS-OCT）得出的前节生物测量值的差异，并评估上述生物测量值与胰岛素样生长因子 1（IGF-1）和生长激素（GH）水平之间的相关性。
本病例对照研究纳入了 30 例肢端肥大症患者的 60 只眼和 30 例正常对照者的 60 只眼。通过 AS-OCT 测量中央角膜厚度、瞳孔直径、虹膜厚度（IT）、虹膜曲率（IC）、前房深度（ACD）、前房宽度、晶状体 vault（LV）、房角开放距离（AOD）500、AOD750、小梁虹膜空间面积（TISA）500 和 TISA750。构建广义线性回归模型以评估影响虹膜形态和前房角（ACA）宽度的独立内分泌因素。
肢端肥大症患者的虹膜更均匀增厚（P < 0.001），IC 更小（P < 0.05），LV 更小（P = 0.040），而 AOD500、AOD750、TISA500 和 TISA750 显著增大（P < 0.001）。肢端肥大症患者的血清 GH 水平与 ACD 呈正相关（P = 0.031）。线性回归模型显示，较低的 LV 和较小的 IC 是 AOD500、AOD750 和 TISA750 以及鼻侧 TISA500 增大的独立影响因素。血清 IGF-1 是瞳孔直径增大的独立因素（β = 0.002，P = 0.031），以及鼻侧（β = 6.78110-5，P = 0.049）和颞侧（β = 7.73610-5，P = 0.045）IT 值增大和颞侧 IC 减小的独立因素（β < 0.001，P = 0.037）。GH 是颞侧 AOD750（β = 0.001，P = 0.030）和颞侧 TISA750（β = 0.002，P = 0.016）增大的独立因素。
与正常对照者相比，肢端肥大症患者的 IT 更厚、IC 更小、LV 更低、ACA 更宽。血清 GH 与颞侧 ACA 宽度独立相关，而血清 IGF-1 与 IT、瞳孔直径和 IC 独立相关。
