有氧运动并不能预测抑郁症患者脑源性神经营养因子和皮质醇的变化。
Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed Patients.
作者信息
Lamego Murilo Khede, de Souza Moura Antonio Marcos, Paes Flávia, Ferreira Rocha Nuno Barbosa, de Sá Filho Alberto Souza, Lattari Eduardo, Rimes Ridson, Manochio João, Budde Henning, Wegner Mirko, Mura Gioia, Arias-Carrión Oscar, Yuan Ti-Fei, Nardi Antonio Egidio, Machado Sergio
机构信息
School of Psychology, Nanjing Normal University, Nanjing, China.
Laboratory of Panic and Respiration, Institute of Psychiatry (IPUB) - Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
出版信息
CNS Neurol Disord Drug Targets. 2015;14(9):1116-28. doi: 10.2174/1871527315666151111125402.
The pathophysiology of depression is related to neurobiological changes that occur in the monoamine system, hypothalamic-pituitary-adrenal axis, neurogenesis system and the neuroimmune system. In recent years, there has been a growing interest in the research of the effects of exercise on brain function, with a special focus on its effects on brain-derived neurotrophic factor (BDNF), cortisol and other biomarkers. Thus, the aim of this study is to present a review investigating the acute and chronic effects of aerobic exercise on BDNF and cortisol levels in individuals with depression. It was not possible to establish an interaction between aerobic exercise and concentration of BDNF and cortisol, which may actually be the result of the divergence of methods, such as type of exercises, duration of the sessions, and prescribed intensity and frequency of sessions.
抑郁症的病理生理学与单胺系统、下丘脑-垂体-肾上腺轴、神经发生系统和神经免疫系统中发生的神经生物学变化有关。近年来，人们对运动对脑功能影响的研究兴趣日益浓厚，特别关注其对脑源性神经营养因子（BDNF）、皮质醇和其他生物标志物的影响。因此，本研究的目的是综述有氧运动对抑郁症患者BDNF和皮质醇水平的急性和慢性影响。有氧运动与BDNF和皮质醇浓度之间无法建立相互作用，这实际上可能是由于方法上的差异导致的，如运动类型、训练时长以及规定的训练强度和频率。
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