Rojas Vega Sandra, Strüder Heiko K, Vera Wahrmann Bertha, Schmidt Annette, Bloch Wilhelm, Hollmann Wildor
Institute of Motor Control and Movement Technique, German Sport University Cologne, Carl-Diem-Weg 6, 50933 Cologne, Germany.
Brain Res. 2006 Nov 22;1121(1):59-65. doi: 10.1016/j.brainres.2006.08.105. Epub 2006 Sep 28.
The effect of short-term aerobic exercise and a following ramp incremental cycle ergometry to exhaustion on the acute response of the serum concentrations of brain derived neurotrophic factor (BDNF) and cortisol (COR) was examined in 8 healthy male athletes. Venous and capillary blood samples were drawn at rest, immediately after a 10 min warm-up period with aerobic exercise and after a ramp test to exhaustion, as well as 3, 6, 10 and 15 min post exercise. Capillary blood lactate (LA) concentration and blood gases as well as serum BDNF and COR concentrations did not change during the warm-up period. LA was increased (p<0.05) at the end of the ramp test and during recovery period while bicarbonate concentration, carbon dioxide pressure, pH and base excess were decreased (p<0.05) during this period. Serum BDNF was increased at the point of exhaustion (p<0.05) while no significant differences were found between values at rest and those during recovery period. At 10 and 15 min post incremental exercise, COR concentrations were increased (p<0.05) compared to rest. The present study is the first to demonstrate in humans that in contrast to short duration aerobic exercise immediately after a following short duration high-intensity exercise to exhaustion, there is a transient augmentation of serum BDNF concentration. Short-term response of serum BDNF and COR concentrations differs as BDNF returns to baseline level faster than COR.
在8名健康男性运动员中，研究了短期有氧运动以及随后进行递增负荷循环测力计运动直至力竭对血清脑源性神经营养因子（BDNF）和皮质醇（COR）浓度急性反应的影响。在静息状态、有氧运动10分钟热身期结束后、递增负荷运动至力竭后以及运动后3、6、10和15分钟采集静脉血和毛细血管血样本。在热身期，毛细血管血乳酸（LA）浓度、血气以及血清BDNF和COR浓度均未发生变化。在递增负荷运动结束时和恢复期间，LA升高（p<0.05），而在此期间，碳酸氢盐浓度、二氧化碳分压、pH值和碱剩余降低（p<0.05）。血清BDNF在力竭时升高（p<0.05），而静息值与恢复期间的值之间未发现显著差异。在递增运动后10和15分钟，COR浓度与静息时相比升高（p<0.05）。本研究首次在人体中证明，与短时间有氧运动后紧接着进行短时间高强度运动直至力竭不同，血清BDNF浓度会出现短暂升高。血清BDNF和COR浓度的短期反应不同，因为BDNF比COR更快恢复到基线水平。
