运动强度对青少年脑源性神经营养因子和记忆力的影响。
The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents.
机构信息
Department of Physical Education, Dankook University, Yongin, Republic of Korea.
Department Human Performance and Leisure Studies, North Carolina A&T State University, 1601 E. Market Street, Greensboro, NC, 27411, USA.
出版信息
Environ Health Prev Med. 2017 Apr 4;22(1):27. doi: 10.1186/s12199-017-0643-6.
BACKGROUND
Brain derived neurotrophic factor (BDNF) seems to serve as an important regulatory mechanism in the growth and development of neurons in many areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to neurogenesis and regulation of the BDNF gene and is involved in the growth and differentiation of neurons.Cortisol is released in response to stimuli such as psychological oppression, anxiety, and fear. Stress also induces changes in BDNF. The purpose of this study was thus to examine the effects of varying intensities of aerobic exercise on resting serum BDNF, IGF-1 concentrations, cortisol, and memory of adolescents.
METHODS
Forty male students with no history of physical illness from the middle school by participated in this study. Participants were randomly assigned to low, moderate, or high intensity treadmill exercise group, or a stretching (control) group. Exercise was performed 4 times per week for 12 weeks. Body composition, brain derived neurotrophic factor levels, insulin-like growth factor 1 levels, cortisol levels, and working memory were assessed.
RESULTS
The high intensity exercise group showed a significant increase in brain derived neurotrophic factor at rest, concentration level of insulin-like growth factor 1, cortisol, and working memory. For resting brain derived neurotrophic factor, the high intensity exercise group showed a more significant increase compared to the low intensity aerobic and stretching groups. The change in the working memory significantly increased for the high intensity exercise group compared to the low intensity aerobic group, moderate intensity exercise group, and stretching group.
CONCLUSIONS
In adolescents, whose brains are still developing, aerobic exercise of moderate to high intensity levels seems to have a positive effect on levels of serum brain derived neurotrophic factor at rest and on cognitive functioning.
TRIAL REGISTRATION
EHPM-D-16-00107R2 . ICMJE. 12 July 2016.
背景
脑源性神经营养因子（BDNF）似乎是大脑许多区域神经元生长和发育的重要调节机制。胰岛素样生长因子 1（IGF-1）与神经发生和 BDNF 基因的调节有关，并参与神经元的生长和分化。皮质醇是对心理压迫、焦虑和恐惧等刺激的反应而释放的。压力也会引起 BDNF 的变化。因此，本研究旨在探讨不同强度的有氧运动对青少年静息血清 BDNF、IGF-1 浓度、皮质醇和记忆力的影响。
方法
从中学招募了 40 名无病史的男性学生参加了这项研究。参与者被随机分配到低强度、中强度或高强度跑步机运动组或拉伸（对照）组。每周运动 4 次，持续 12 周。评估身体成分、脑源性神经营养因子水平、胰岛素样生长因子 1 水平、皮质醇水平和工作记忆。
结果
高强度运动组静息时脑源性神经营养因子水平、胰岛素样生长因子 1 浓度、皮质醇和工作记忆显著升高。与低强度有氧运动和拉伸组相比，高强度运动组静息时脑源性神经营养因子的增加更为显著。与低强度有氧运动组、中强度有氧运动组和拉伸组相比，高强度运动组的工作记忆变化显著增加。
结论
在大脑仍在发育的青少年中，中高强度水平的有氧运动似乎对静息时血清脑源性神经营养因子水平和认知功能有积极影响。
试验注册号
EHPM-D-16-00107R2 。国际医学期刊编辑委员会（ICMJE）。2016 年 7 月 12 日。
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