脑源性神经营养因子（Bdnf）与睡眠对抑郁症的影响：综述
Relationship Between Brain-Derived Neurotrofic Factor (Bdnf) and Sleep on Depression: A Critical Review.
作者信息
Monteiro Bárbara C, Monteiro Suzana, Candida Maristela, Adler Nathalia, Paes Flavia, Rocha Nuno, Nardi Antonio Egidio, Murillo-Rodriguez Eric, Machado Sergio
机构信息
Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Polytechnic Institute of Porto, Health School, , Portugal.
出版信息
Clin Pract Epidemiol Ment Health. 2017 Nov 21;13:213-219. doi: 10.2174/1745017901713010213. eCollection 2017.
Abstract
The Brain-Derived Neurotrofic Factor (BDNF) is one of the most important neurotrophins in the brain and it is suggested influences the activity of the serotonergic, noradrenergic and dopaminergic pathways. In the last few years, it has been hypothesized that BDNF level is related with depression and sleep. Several studies show that depressive subjects present low levels of BDNF in the brain. Poor sleep quality is also related with alterations in the BDNF concentration. Some authors argue that most of the cases show that impaired sleep quality increases the stress and, consequently, the vulnerability to depressive disorders, suggesting that there is a relationship between sleep, depression and BDNF levels.
摘要
脑源性神经营养因子（BDNF）是大脑中最重要的神经营养因子之一，据推测它会影响血清素能、去甲肾上腺素能和多巴胺能通路的活性。在过去几年中，有人提出BDNF水平与抑郁症和睡眠有关。多项研究表明，抑郁症患者大脑中的BDNF水平较低。睡眠质量差也与BDNF浓度的改变有关。一些作者认为，大多数情况表明睡眠质量受损会增加压力，进而增加患抑郁症的易感性，这表明睡眠、抑郁症和BDNF水平之间存在关联。
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