Şirli Roxana, Sporea Ioan, Popescu Alina, Dănilă Mirela
Roxana Şirli, Ioan Sporea, Alina Popescu, Mirela Dănilă, Department of Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy, 300736 Timişoara, Romania.
World J Gastroenterol. 2015 Nov 7;21(41):11542-51. doi: 10.3748/wjg.v21.i41.11542.
Progressive fibrosis is encountered in almost all chronic liver diseases. Its clinical signs are diagnostic in advanced cirrhosis, but compensated liver cirrhosis is harder to diagnose. Liver biopsy is still considered the reference method for staging the severity of fibrosis, but due to its drawbacks (inter and intra-observer variability, sampling errors, unequal distribution of fibrosis in the liver, and risk of complications and even death), non-invasive methods were developed to assess fibrosis (serologic and elastographic). Elastographic methods can be ultrasound-based or magnetic resonance imaging-based. All ultrasound-based elastographic methods are valuable for the early diagnosis of cirrhosis, especially transient elastography (TE) and acoustic radiation force impulse (ARFI) elastography, which have similar sensitivities and specificities, although ARFI has better feasibility. TE is a promising method for predicting portal hypertension in cirrhotic patients, but it cannot replace upper digestive endoscopy. The diagnostic accuracy of using ARFI in the liver to predict portal hypertension in cirrhotic patients is debatable, with controversial results in published studies. The accuracy of ARFI elastography may be significantly increased if spleen stiffness is assessed, either alone or in combination with liver stiffness and other parameters. Two-dimensional shear-wave elastography, the ElastPQ technique and strain elastography all need to be evaluated as predictors of portal hypertension.
几乎在所有慢性肝病中都会出现进行性纤维化。其临床体征在晚期肝硬化中具有诊断价值,但代偿期肝硬化则更难诊断。肝活检仍被视为评估纤维化严重程度的参考方法,但由于其存在缺点(观察者间和观察者内的变异性、抽样误差、肝脏内纤维化分布不均以及并发症甚至死亡风险),因此开发了非侵入性方法来评估纤维化(血清学和弹性成像)。弹性成像方法可以基于超声或基于磁共振成像。所有基于超声的弹性成像方法对于肝硬化的早期诊断都很有价值,尤其是瞬时弹性成像(TE)和声辐射力脉冲(ARFI)弹性成像,它们具有相似的敏感性和特异性,尽管ARFI的可行性更好。TE是预测肝硬化患者门静脉高压的一种有前景的方法,但它不能替代上消化道内镜检查。在肝脏中使用ARFI预测肝硬化患者门静脉高压的诊断准确性存在争议,已发表的研究结果相互矛盾。如果单独评估脾脏硬度或与肝脏硬度及其他参数联合评估,ARFI弹性成像的准确性可能会显著提高。二维剪切波弹性成像、ElastPQ技术和应变弹性成像都需要作为门静脉高压的预测指标进行评估。