妊娠期高血压疾病似乎与晚年的阿尔茨海默病无关。
Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life.
作者信息
Abheiden Carolien N H, van Doornik Rebecca, Aukes Annet M, van der Flier Wiesje M, Scheltens Philip, de Groot Christianne J M
机构信息
Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands.
Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands ; Department of Epidemiology and Biostatistics, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
出版信息
Dement Geriatr Cogn Dis Extra. 2015 Sep 30;5(3):375-85. doi: 10.1159/000439043. eCollection 2015 Sep-Dec.
BACKGROUND
After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD).
AIM
To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD.
METHODS
A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed.
RESULTS
The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD.
CONCLUSION
A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.
背景
与正常妊娠后的女性相比，妊娠高血压疾病患者报告有更多主观认知主诉和白质病变。两者均与阿尔茨海默病（AD）存在因果关系。
目的
调查妊娠合并高血压疾病的女性患AD的风险是否增加。
方法
在阿姆斯特丹VU大学医学中心阿尔茨海默病中心对患有AD的女性和未患AD的女性进行病例对照研究。采用纸质和电话调查。
结果
应答率为85.2%。未发现有（n = 104）和无AD（n = 129）且报告妊娠合并高血压疾病的女性之间存在关联（p = 0.11）。与晚发型AD女性相比，早发型AD女性报告妊娠高血压疾病的频率更高（p = 0.02）。
结论
报告的妊娠高血压疾病病史似乎与晚年患AD无关。
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