Yoshida Tadao, Teranishi Masaaki, Iwata Tomoyuki, Otake Hironao, Nakashima Tsutomu
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Audiol Res. 2012 Jan 9;2(1):e2. doi: 10.4081/audiores.2011.e2.
The purpose of this study is to test the effectiveness of intratympanic dexamethasone injections as a treatment for severe tinnitus in idiopathic sudden sensorineural hearing loss (SNHL). We studied 37 patients who received intratympanic dexamethasone injections and 14 control patients who did not receive it, with severe tinnitus after onset of unilateral sudden SNHL. Hearing level did not change during this study in any patient. The relationship between the duration of tinnitus and effectiveness of treatment was investigated in sudden SNHL. We used a visual analogue scale to evaluate 51 patients with severe tinnitus at the stage of stable hearing level after idiopathic sudden sensorineural hearing loss. Forty-one per cent of patients showed significant improvement after treatment. The average period between onset of sudden sensorineural hearing loss and initiation of intratympanic dexamethasone injection was significantly shorter (207 days) in the improved group than in the unchanged group (482 days) (P<0.001). In control group, one of 14 patients presented significant improvement spontaneously. Intratympanic dexamethasone treatment may be effective in treatment of severe tinnitus after sudden SNHL at the stage of stable hearing level, and the shorter the period from onset of sudden deafness to the start of intratympanic dexamethasone treatment, the greater the improvement in tinnitus that can be expected.
本研究的目的是测试鼓室内注射地塞米松治疗特发性突发性感音神经性听力损失（SNHL）所致严重耳鸣的有效性。我们研究了37例接受鼓室内注射地塞米松的患者以及14例未接受该治疗的对照患者，这些患者均在单侧突发SNHL发病后出现严重耳鸣。在本研究期间，所有患者的听力水平均未发生变化。我们对突发SNHL患者耳鸣持续时间与治疗效果之间的关系进行了调查。我们使用视觉模拟量表对51例在特发性突发性感音神经性听力损失后听力水平稳定阶段出现严重耳鸣的患者进行评估。41%的患者在治疗后有显著改善。改善组突发性感音神经性听力损失发作与开始鼓室内注射地塞米松之间的平均时间（207天）明显短于未改善组（482天）（P<0.001）。在对照组中，14例患者中有1例自发出现显著改善。鼓室内注射地塞米松治疗在听力水平稳定阶段的突发SNHL后严重耳鸣的治疗中可能有效，并且从突发性耳聋发作到开始鼓室内注射地塞米松治疗的时间越短，耳鸣有望得到的改善就越大。
