一名患有自身免疫性肝炎和IgG4亚类缺乏症的免疫抑制患者发生单核细胞增生李斯特菌脑膜炎。
Listeria monocytogenes Meningitis in an Immunosuppressed Patient with Autoimmune Hepatitis and IgG4 Subclass Deficiency.
作者信息
Gaini Shahin
机构信息
Infectious Diseases Division, Medical Department, National Hospital Faroe Islands, 100 Tórshavn, Faroe Islands ; Infectious Diseases Research Unit, Odense University Hospital and University of Southern Denmark, 5000 Odense, Denmark.
出版信息
Case Rep Infect Dis. 2015;2015:102451. doi: 10.1155/2015/102451. Epub 2015 Oct 19.
A 51-year-old Caucasian woman with Listeria monocytogenes meningitis was treated and discharged after an uncomplicated course. Her medical history included immunosuppressive treatment with prednisolone and azathioprine for autoimmune hepatitis. A diagnostic work-up after the meningitis episode revealed that she had low levels of the IgG4 subclass. To our knowledge, this is the first case report describing a possible association between autoimmune hepatitis and the occurrence of Listeria monocytogenes meningitis, describing a possible association between Listeria monocytogenes meningitis and deficiency of the IgG4 subclass and finally describing a possible association between Listeria monocytogenes meningitis and immunosuppressive therapy with prednisolone and azathioprine.
一名51岁患有单核细胞增生李斯特菌脑膜炎的白种女性，经治疗后病程顺利并出院。她的病史包括因自身免疫性肝炎接受泼尼松龙和硫唑嘌呤的免疫抑制治疗。脑膜炎发作后的诊断检查显示她的IgG4亚类水平较低。据我们所知，这是首例描述自身免疫性肝炎与单核细胞增生李斯特菌脑膜炎发生之间可能关联、单核细胞增生李斯特菌脑膜炎与IgG4亚类缺乏之间可能关联，以及最终描述单核细胞增生李斯特菌脑膜炎与泼尼松龙和硫唑嘌呤免疫抑制治疗之间可能关联的病例报告。
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