乳糜泻的年龄相关差异：成人发病的特定特征
Age-related differences in celiac disease: Specific characteristics of adult presentation.
作者信息
Vivas Santiago, Vaquero Luis, Rodríguez-Martín Laura, Caminero Alberto
机构信息
Santiago Vivas, Institute of Biomedicine (IBIOMED), University of León, 24008 León, Spain.
出版信息
World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):207-12. doi: 10.4292/wjgpt.v6.i4.207.
Abstract
Celiac disease may appear both in early childhood and in elderly subjects. Current knowledge of the disease has revealed some differences associated to the age of presentation. Furthermore, monitoring and prognosis of celiac subjects can vary depending on the pediatric or adult stage. The main objective of this review is to provide guidance for the adult diagnostic and follow-up processes, which must be tailored specifically for adults and be different from pediatric patients.
摘要
乳糜泻可出现在儿童早期和老年人群中。目前对该疾病的认识揭示了一些与发病年龄相关的差异。此外，乳糜泻患者的监测和预后可能因处于儿童期或成年期而有所不同。本综述的主要目的是为成人诊断和随访过程提供指导，这些过程必须专门针对成人量身定制，且与儿科患者不同。
相似文献
1
Age-related differences in celiac disease: Specific characteristics of adult presentation.乳糜泻的年龄相关差异：成人发病的特定特征
World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):207-12. doi: 10.4292/wjgpt.v6.i4.207.
2
Monitoring nonresponsive patients who have celiac disease.监测患有乳糜泻的无反应患者。
Gastrointest Endosc Clin N Am. 2006 Apr;16(2):317-27. doi: 10.1016/j.giec.2006.03.005.
3
Diagnosis of Celiac Disease: Taking a Bite Out of the Controversy.乳糜泻的诊断：解决争议的关键。
Dig Dis Sci. 2018 Jun;63(6):1384-1391. doi: 10.1007/s10620-018-5050-3.
4
Long-term follow-up of celiac adults on gluten-free diet: prevalence and correlates of intestinal damage.乳糜泻成年患者无麸质饮食的长期随访：肠道损伤的患病率及相关因素
Digestion. 2002;66(3):178-85. doi: 10.1159/000066757.
5
Celiac disease in children.儿童乳糜泻
Minerva Pediatr. 2019 Feb;71(1):39-46. doi: 10.23736/S0026-4946.18.05366-5. Epub 2018 Jul 18.
6
Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity.麸质相关疾病的诊断：乳糜泻、小麦过敏和非乳糜泻性麸质敏感。
World J Gastroenterol. 2015 Jun 21;21(23):7110-9. doi: 10.3748/wjg.v21.i23.7110.
7
A Comprehensive Review of Celiac Disease/Gluten-Sensitive Enteropathies.乳糜泻/麸质敏感肠病的全面综述。
Clin Rev Allergy Immunol. 2019 Oct;57(2):226-243. doi: 10.1007/s12016-018-8691-2.
8
Co-occurrence of eosinophilic esophagitis and potential/probable celiac disease in an adult cohort: a possible association with implications for clinical practice.成年队列中嗜酸性粒细胞性食管炎与潜在/可能的乳糜泻的共现：一种可能的关联及其对临床实践的影响。
Dis Esophagus. 2016 Nov;29(8):977-982. doi: 10.1111/dote.12419. Epub 2015 Nov 6.
9
Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes.未经治疗的儿童和成人乳糜泻患者肠 T 细胞对脱酰胺麸质表位的相似反应。
Gastroenterology. 2017 Sep;153(3):787-798.e4. doi: 10.1053/j.gastro.2017.05.016. Epub 2017 May 20.
10
A highly accurate method for monitoring histological recovery in patients with celiac disease on a gluten-free diet using an endoscopic approach that avoids the need for biopsy: a double-center study.一种使用内镜方法监测乳糜泻患者在无麸质饮食时组织学恢复情况的高度准确的方法，该方法无需活检：一项双中心研究。
Endoscopy. 2007 Jan;39(1):46-51. doi: 10.1055/s-2006-945044.
引用本文的文献
1
Altered miRNA expression in duodenal tissue of celiac patients and the impact of a gluten-free diet: a preliminary study.乳糜泻患者十二指肠组织中miRNA表达的改变及无麸质饮食的影响：一项初步研究。
Mol Biol Rep. 2025 Apr 30;52(1):441. doi: 10.1007/s11033-025-10534-y.
2
Clinical Spectrum of Celiac Disease among Adult Population: Experience from Largest Tertiary Care Hospital in Karachi, Pakistan.巴基斯坦卡拉奇最大的三级医疗医院的经验：成人乳糜泻的临床谱
Euroasian J Hepatogastroenterol. 2024 Jan-Jun;14(1):24-29. doi: 10.5005/jp-journals-10018-1420.
3
More Than Three Years for Normalisation of Routine Laboratory Values after Gluten Withdrawal in Paediatric Coeliac Patients.小儿乳糜泻患者停用麸质后，常规实验室检查值恢复正常需要三年多时间。
Children (Basel). 2023 Sep 21;10(9):1580. doi: 10.3390/children10091580.
4
Prevalence of vomiting and nausea and associated factors after chronic and acute gluten exposure in celiac disease.乳糜泻患者慢性和急性麸质暴露后呕吐和恶心的发生率及相关因素。
BMC Gastroenterol. 2023 Sep 6;23(1):301. doi: 10.1186/s12876-023-02934-w.
5
Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients.《日本患者的乳糜泻遗传学、发病机制和标准治疗》
Int J Mol Sci. 2023 Jan 20;24(3):2075. doi: 10.3390/ijms24032075.
6
Celiac Disease and Thrombotic Events: Systematic Review of Published Cases.乳糜泻与血栓事件：已发表病例的系统综述。
Nutrients. 2022 May 23;14(10):2162. doi: 10.3390/nu14102162.
7
An Investigation Into What Factors Influence Patterns of Clinical Presentation in Adult-Onset Celiac Disease.成人乳糜泻临床表现模式的影响因素调查
Cureus. 2022 Feb 5;14(2):e21924. doi: 10.7759/cureus.21924. eCollection 2022 Feb.
8
The costs of celiac disease: a contingent valuation in Switzerland.乳糜泻的成本：瑞士的条件价值评估。
Eur J Health Econ. 2021 Dec;22(9):1487-1505. doi: 10.1007/s10198-021-01376-z. Epub 2021 Oct 7.
9
Peripheral T-Cell Lymphoma Possibly Due to Unrecognized Celiac Disease in an Elderly Patient: A Case Report.老年患者外周 T 细胞淋巴瘤可能与未识别的乳糜泻有关：病例报告。
Medicina (Kaunas). 2021 May 11;57(5):471. doi: 10.3390/medicina57050471.
10
Multidimensional Disadvantages of a Gluten-Free Diet in Celiac Disease: A Narrative Review.乳糜泻患者无麸质饮食的多维弊端：叙事性综述。
Nutrients. 2021 Feb 16;13(2):643. doi: 10.3390/nu13020643.
本文引用的文献
1
The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center.乳糜泻不断变化的临床特征：意大利一家转诊中心的15年经验（1998 - 2012年）
BMC Gastroenterol. 2014 Nov 18;14:194. doi: 10.1186/s12876-014-0194-x.
2
Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology.成人乳糜泻的诊断和管理：英国胃肠病学会指南。
Gut. 2014 Aug;63(8):1210-28. doi: 10.1136/gutjnl-2013-306578. Epub 2014 Jun 10.
3
Coeliac disease screening in first-degree relatives on the basis of biopsy and genetic risk.基于活检和遗传风险对一级亲属进行乳糜泻筛查。
Eur J Gastroenterol Hepatol. 2014 Mar;26(3):263-7. doi: 10.1097/MEG.0000000000000020.
4
Celiac disease and autoimmune-associated conditions.乳糜泻与自身免疫相关疾病。
Biomed Res Int. 2013;2013:127589. doi: 10.1155/2013/127589. Epub 2013 Jul 24.
5
Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study.乳糜泻黏膜愈合与淋巴增生性恶性肿瘤风险：基于人群的队列研究。
Ann Intern Med. 2013 Aug 6;159(3):169-75. doi: 10.7326/0003-4819-159-3-201308060-00006.
6
Systematic review: worldwide variation in the frequency of coeliac disease and changes over time.系统评价：世界各地乳糜泻的发病率变化及其时间趋势。
Aliment Pharmacol Ther. 2013 Aug;38(3):226-45. doi: 10.1111/apt.12373. Epub 2013 Jun 18.
7
Is it worth investigating splenic function in patients with celiac disease?是否有必要对乳糜泻患者的脾脏功能进行研究？
World J Gastroenterol. 2013 Apr 21;19(15):2313-8. doi: 10.3748/wjg.v19.i15.2313.
8
Prevalence of irritable bowel syndrome-type symptoms in patients with celiac disease: a meta-analysis.乳糜泻患者肠易激综合征样症状的患病率：一项荟萃分析。
Clin Gastroenterol Hepatol. 2013 Apr;11(4):359-65.e1. doi: 10.1016/j.cgh.2012.11.033. Epub 2012 Dec 13.
9
The prevalence of celiac disease in the United States.美国的乳糜泻患病率。
Am J Gastroenterol. 2012 Oct;107(10):1538-44; quiz 1537, 1545. doi: 10.1038/ajg.2012.219. Epub 2012 Jul 31.
10
Differences in faecal bacteria populations and faecal bacteria metabolism in healthy adults and celiac disease patients.健康成年人和乳糜泻患者粪便细菌种群和粪便细菌代谢的差异。
Biochimie. 2012 Aug;94(8):1724-9. doi: 10.1016/j.biochi.2012.03.025. Epub 2012 Apr 20.
Zotero 插件