Ampatzoglou Pantelis, Dassios George, Hadjinicolaou Maria, Kourea Helen P, Vrahatis Michael N
School of Science and Technology, Hellenic Open University, Sachtouri 11, 26222 Patras, Greece.
Department of Chemical Engineering, University of Patras, Patras, Greece.
Springerplus. 2015 Nov 2;4:660. doi: 10.1186/s40064-015-1417-5. eCollection 2015.
In the present manuscript we propose a lattice free multiscale model for avascular tumor growth that takes into account the biochemical environment, mitosis, necrosis, cellular signaling and cellular mechanics. This model extends analogous approaches by assuming a function that incorporates the biochemical energy level of the tumor cells and a mechanism that simulates the behavior of cancer stem cells. Numerical simulations of the model are used to investigate the morphology of the tumor at the avascular phase. The obtained results show similar characteristics with those observed in clinical data in the case of the Ductal Carcinoma In Situ (DCIS) of the breast.
在本论文中，我们提出了一种用于无血管肿瘤生长的无网格多尺度模型，该模型考虑了生化环境、有丝分裂、坏死、细胞信号传导和细胞力学。通过假设一个纳入肿瘤细胞生化能量水平的函数和一个模拟癌症干细胞行为的机制，此模型扩展了类似的方法。利用该模型的数值模拟来研究肿瘤在无血管阶段的形态。所得结果显示出与乳腺导管原位癌（DCIS）临床数据中观察到的特征相似。
