硫酸乙酰肝素蛋白聚糖可能通过与整合素相互作用并影响细胞迁移来促进或抑制癌症进展。
Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration.
作者信息
Soares Mariana A, Teixeira Felipe C O B, Fontes Miguel, Arêas Ana Lúcia, Leal Marcelo G, Pavão Mauro S G, Stelling Mariana P
机构信息
Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil.
Serviço de Patologia, Hospital Naval Marcílio Dias, 20725-090 Rio de Janeiro, RJ, Brazil.
出版信息
Biomed Res Int. 2015;2015:453801. doi: 10.1155/2015/453801. Epub 2015 Oct 19.
The metastatic disease is one of the main consequences of tumor progression, being responsible for most cancer-related deaths worldwide. This review intends to present and discuss data on the relationship between integrins and heparan sulfate proteoglycans in health and cancer progression. Integrins are a family of cell surface transmembrane receptors, responsible for cell-matrix and cell-cell adhesion. Integrins' main functions include cell adhesion, migration, and survival. Heparan sulfate proteoglycans (HSPGs) are cell surface molecules that play important roles as cell receptors, cofactors, and overall direct or indirect contributors to cell organization. Both molecules can act in conjunction to modulate cell behavior and affect malignancy. In this review, we will discuss the different contexts in which various integrins, such as α5, αV, β1, and β3, interact with HSPGs species, such as syndecans and perlecans, affecting tissue homeostasis.
转移性疾病是肿瘤进展的主要后果之一，在全球范围内导致了大多数与癌症相关的死亡。本综述旨在呈现并讨论关于整合素与硫酸乙酰肝素蛋白聚糖在健康和癌症进展中的关系的数据。整合素是一类细胞表面跨膜受体家族，负责细胞与基质以及细胞与细胞之间的黏附。整合素的主要功能包括细胞黏附、迁移和存活。硫酸乙酰肝素蛋白聚糖（HSPGs）是细胞表面分子，作为细胞受体、辅助因子以及细胞组织的整体直接或间接贡献者发挥重要作用。这两种分子可以共同作用来调节细胞行为并影响恶性肿瘤。在本综述中，我们将讨论各种整合素（如α5、αV、β1和β3）与硫酸乙酰肝素蛋白聚糖种类（如多配体蛋白聚糖和基底膜蛋白聚糖）相互作用的不同情况，这些相互作用会影响组织稳态。
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