与结核病易感性相关基因的表观遗传修饰及其对表观遗传药物的意义
The Epigenetic Modifications of Genes Associated with Tuberculosis Susceptibility and Implications for Epi-Drugs.
作者信息
Zeng Jie, Xie Longxiang, Luo Hongping, Xie Jianping
机构信息
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Three Gorges Eco-Environment and Bioresources, Eco-Environment Key Laboratory of the Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest Uni.
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China.
出版信息
Crit Rev Eukaryot Gene Expr. 2015;25(4):349-62. doi: 10.1615/critreveukaryotgeneexpr.2015014334.
Epigenetics of genes associated with tuberculosis susceptibility such as DNA methylation, posttranslational histone modifications, and non-coding RNA remain largely untapped field for better tuberculosis control. Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification. Our summary of these modifications provides fresh insights into the pathogenesis of tuberculosis and inspires targets discovery for host-derived therapy.
与结核病易感性相关基因的表观遗传学，如DNA甲基化、翻译后组蛋白修饰和非编码RNA，在很大程度上仍是尚未开发的领域，以实现更好的结核病控制。许多参与结核病易感性的基因（如NRAMP1（SLC11A1）、IFNG、NOS2A、VDR、ISG15、TACO、TLR1、TLR、IL18R1、趋化因子、PADI、DUSP14、MBL和MASP-2）已发生表观遗传修饰。我们对这些修饰的总结为结核病发病机制提供了新的见解，并为宿主源性治疗的靶点发现提供了启发。
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