遗传和环境因素对腹主动脉直径发育的影响。
Genetic and Environmental Effects on the Abdominal Aortic Diameter Development.
作者信息
Tarnoki Adam Domonkos, Tarnoki David Laszlo, Littvay Levente, Garami Zsolt, Karlinger Kinga, Berczi Viktor
机构信息
Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.
Central European University, Budapest, Hungary.
出版信息
Arq Bras Cardiol. 2016 Jan;106(1):13-7. doi: 10.5935/abc.20150140. Epub 2015 Nov 10.
BACKGROUND
Configuration of the abdominal aorta is related to healthy aging and a variety of disorders.
OBJECTIVES
We aimed to assess heritable and environmental effects on the abdominal aortic diameter.
METHODS
114 adult (69 monozygotic, 45 same-sex dizygotic) twin pairs (mean age 43.6 ± 16.3 years) underwent abdominal ultrasound with Esaote MyLab 70X ultrasound machine to visualize the abdominal aorta below the level of the origin of the renal arteries and 1-3 cm above the bifurcation.
RESULTS
Age- and sex-adjusted heritability of the abdominal aortic diameter below the level of the origin of the renal arteries was 40% [95% confidence interval (CI), 14 to 67%] and 55% above the aortic bifurcation (95% CI, 45 to 70%). None of the aortic diameters showed common environmental effects, but unshared environmental effects were responsible for 60% and 45% of the traits, respectively.
CONCLUSIONS
Our analysis documents the moderate heritability and its segment-specific difference of the abdominal aortic diameter. The moderate part of variance was explained by unshared environmental components, emphasizing the importance of lifestyle factors in primary prevention. Further studies in this field may guide future gene-mapping efforts and investigate specific lifestyle factors to prevent abdominal aortic dilatation and its complications.
背景
腹主动脉的形态与健康衰老及多种疾病相关。
目的
我们旨在评估遗传和环境因素对腹主动脉直径的影响。
方法
114对成年双胞胎（69对同卵双胞胎，45对同性异卵双胞胎）（平均年龄43.6±16.3岁）使用百胜MyLab 70X超声仪进行腹部超声检查，以观察肾动脉起始水平以下及分叉上方1 - 3厘米处的腹主动脉。
结果
经年龄和性别调整后，肾动脉起始水平以下腹主动脉直径的遗传度为40%[95%置信区间（CI），14%至67%]，主动脉分叉上方为55%（95%CI，45%至70%）。所有主动脉直径均未显示出共同环境效应，但非共享环境效应分别占这些性状的60%和45%。
结论
我们的分析记录了腹主动脉直径的中度遗传度及其节段特异性差异。变异的中度部分由非共享环境因素解释，强调了生活方式因素在一级预防中的重要性。该领域的进一步研究可能会指导未来的基因定位工作，并研究预防腹主动脉扩张及其并发症的特定生活方式因素。
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