Morgan B P
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK.
Complement Inflamm. 1989;6(2):104-11. doi: 10.1159/000463082.
This article explores the role of the cytolytic membrane attack complex of complement in the pathogenesis of inflammatory diseases. Evidence of nucleated cell resistance to lysis by the membrane attack complex and the stimulation of secretion of pro-inflammatory factors in the absence of cell death in a variety of cell types in vitro are documented, and the possible significance of these non-lethal effects to the pathogenesis of inflammatory diseases highlighted.
本文探讨补体的溶细胞性膜攻击复合物在炎症性疾病发病机制中的作用。有文献记载了在体外多种细胞类型中，有核细胞对膜攻击复合物介导的细胞溶解具有抗性，以及在无细胞死亡的情况下促炎因子分泌受到刺激，并强调了这些非致死性效应在炎症性疾病发病机制中的可能意义。
