Fasoli M, Parazzini F, Cecchetti G, La Vecchia C
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Contraception. 1989 Apr;39(4):459-68. doi: 10.1016/0010-7824(89)90123-6.
Information from published studies testing the effect of hormonal and mechanical interceptive methods in post-coital contraception was pooled with the aim of assessing the efficacy of various regimens. The pooled failure rates were 0.6% (19/3168 based on four studies) for high-dosage ethinylestradiol, 1.1% (11/975, based on two studies) for other high-dose estrogens, 1.8% (69/3802 based on 11 studies) for combined estro-progestin preparations, 2.0% (20/998 based on three studies) for danazol and 0.1% (1/879 based on nine studies) for intra-uterine devices (IUD). Although this overview has several limitations in terms of over-representation of optimistic results in the literature or absence of direct comparison between treatments in several studies, it suggests that IUD and high-dose ethinylestradiol are more efficacious forms of post-coital contraception than danazol or combined contraceptives.
为评估各种方案的疗效，我们汇总了已发表研究中关于激素和机械性事后避孕方法效果的信息。高剂量炔雌醇的汇总失败率为0.6%（基于四项研究，3168例中有19例失败），其他高剂量雌激素为1.1%（基于两项研究，975例中有11例失败），雌孕激素联合制剂为1.8%（基于11项研究，3802例中有69例失败），达那唑为2.0%（基于三项研究，998例中有20例失败），宫内节育器（IUD）为0.1%（基于九项研究，879例中有1例失败）。尽管该综述在文献中乐观结果的过度呈现或多项研究中治疗方法之间缺乏直接比较方面存在若干局限性，但它表明宫内节育器和高剂量炔雌醇比达那唑或复方避孕药更有效地用于事后避孕。
