Kukwa Wojciech, Migacz Ewa, Druc Karolina, Grzesiuk Elzbieta, Czarnecka Anna M
Department of Otorhinolaryngology, Faculty of Medicine & Dentistry, Medical University of Warsaw, 19/25 Stepinska Street, 00-739 Warsaw, Poland.
Laboratory of Molecular Oncology, Department of Oncology, Military Institute of Medicine, 128 Szaserow Street, 04-141 Warsaw, Poland.
Future Oncol. 2015;11(24):3285-98. doi: 10.2217/fon.15.216. Epub 2015 Nov 12.
Obstructive sleep apnea (OSA) is a common disorder characterized by pauses in regular breathing. Apneic episodes lead to recurrent hypoxemia-reoxygenation cycles with concomitant cellular intermittent hypoxia. Studies suggest that intermittent hypoxia in OSA may influence tumorigenesis. This review presents recent articles on the potential role of OSA in cancer development. Relevant research has focused on: molecular pathways mediating the influence of intermittent hypoxia on tumor physiology, animal and epidemiological human studies linking OSA and cancer. Current data relating OSA to risk of neoplastic disease remain scarce, but recent studies reveal the potential for a strong relation. More work is, therefore, needed on the impact of OSA on many cancer-related aspects. Results may offer enlightenment for improved cancer diagnosis and treatment.
阻塞性睡眠呼吸暂停（OSA）是一种常见的疾病，其特征是正常呼吸出现暂停。呼吸暂停发作会导致反复的低氧血症-复氧循环，并伴有细胞间歇性缺氧。研究表明，OSA中的间歇性缺氧可能会影响肿瘤发生。本综述介绍了近期关于OSA在癌症发展中潜在作用的文章。相关研究集中在：介导间歇性缺氧对肿瘤生理学影响的分子途径、将OSA与癌症联系起来的动物和流行病学人体研究。目前将OSA与肿瘤性疾病风险相关的数据仍然稀少，但近期研究揭示了两者之间存在密切关系的可能性。因此，需要进一步研究OSA对许多癌症相关方面的影响。研究结果可能会为改善癌症诊断和治疗提供启示。
