Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan 030001, P.R. China.
The Second Department of Clinical Medicine, Shanxi Medical University, Taiyuan 030000, P.R. China.
Aging (Albany NY). 2020 Feb 29;12(5):4082-4092. doi: 10.18632/aging.102725.
Although observational studies have reported a positive association between obstructive sleep apnea syndrome (OSAS) and breast cancer (BC) risk, causality remains inconclusive. We aim to explore whether OSAS is associated with etiology of BC by conducting a two-sample Mendelian randomization (MR) study in a Chinese population and Asian population from the Breast Cancer Association Consortium (BCAC). We found a detrimental causal effect of OSAS on BC risk in the primary analysis of our samples (IVW OR, 2.47 for BC risk per log-odds increment in OSAS risk, 95% CI = 1.86-3.27; P = 3.6×10). This was very similar to results of the direct observational case-control study between OSAS and BC risk (OR = 2.80; 95% CI = 2.24-3.50; P =1.4×10). Replication in the Asian population of the BCAC study also supported our results (IVW OR, 1.33 for BC risk per log-odds increment in OSAS risk, 95% CI = 1.13-1.56; P = 0.0006). Sensitivity analyses confirmed the robustness of our findings. We provide novel evidence that genetically determined higher risk of OSAS has a causal effect on higher risk of BC. Further studies focused on the mechanisms of the relationship between OSAS and breast carcinogenesis are needed.
虽然观察性研究报告阻塞性睡眠呼吸暂停综合征（OSAS）与乳腺癌（BC）风险之间存在正相关，但因果关系仍不确定。我们旨在通过在中国人群和乳腺癌协会联盟（BCAC）的亚洲人群中进行两样本孟德尔随机化（MR）研究，探讨 OSAS 是否与 BC 的病因学有关。我们发现，在我们样本的主要分析中，OSAS 对 BC 风险存在不利的因果影响（IVW OR，OSAS 风险每增加一个对数几率单位，BC 风险增加 2.47，95%CI=1.86-3.27；P=3.6×10）。这与 OSAS 与 BC 风险之间直接观察性病例对照研究的结果非常相似（OR=2.80；95%CI=2.24-3.50；P=1.4×10）。BCAC 研究亚洲人群的复制也支持了我们的结果（IVW OR，OSAS 风险每增加一个对数几率单位，BC 风险增加 1.33，95%CI=1.13-1.56；P=0.0006）。敏感性分析证实了我们研究结果的稳健性。我们提供了新的证据表明，遗传决定的更高的 OSAS 风险与更高的 BC 风险之间存在因果关系。需要进一步研究集中于 OSAS 和乳腺癌发生之间的关系的机制。
