Sharief Maysoon, Nafee Najlaa Rasmee
Department of Gynecology & Obstetrics, University of Basrah, Basrah, Iraq.
J Pak Med Assoc. 2015 Nov;65(11):1149-52.
To compare the efficacy of letrazole in the induction of ovulation with clomiphene citrate in patients with polycystic ovary syndrome and primary infertility.
The prospective clinical trial was conducted at Basrah Maternity and Child Hospital, Basrah, Iraq, between January 2012 and April 2013, and comprised women with polycystic ovarian syndrome and primary infertility who were randomised into 2 groups. Group A received100-200mg clomiphene citrate daily while group 2 received letrazole (2.5-5mg) daily. Both groups were followed by ultrasound until the dominant follicle reached a diameter >18mm, human chorionic gonadotropin10.000 U/L was given and timed intercourse was advised.
Of the 75 subjects in the study, 40(53.3%) were in group A and 35(46.6%) in group B. The mean age in group A was 25.3+2.1 years versus 26.1+1.3 years in group B (p=0.05). The number of mature follicles was significantly lower, but the endometrial thickness and ovulation were significantly higher in group B than in group A (p<0.05 each). There was no significant difference in pregnancy rate between the two groups (p>0.05).
Letrazole may have a role as the first-line treatment for unovulatory patients with polycystic ovary syndrome.
比较来曲唑与枸橼酸氯米芬对多囊卵巢综合征并原发性不孕患者促排卵的疗效。
2012年1月至2013年4月在伊拉克巴士拉妇幼医院进行了一项前瞻性临床试验，纳入多囊卵巢综合征并原发性不孕的女性，随机分为2组。A组每日服用100 - 200mg枸橼酸氯米芬，B组每日服用来曲唑（2.5 - 5mg）。两组均进行超声监测，直至优势卵泡直径>18mm，给予人绒毛膜促性腺激素10000U/L，并建议适时性交。
研究中的75名受试者中，A组40名（53.3%），B组35名（46.6%）。A组平均年龄为25.3±2.1岁，B组为26.1±1.3岁（p = 0.05）。B组成熟卵泡数量显著低于A组，但子宫内膜厚度和排卵率显著高于A组（均p<0.05）。两组妊娠率无显著差异（p>0.05）。
来曲唑可能作为多囊卵巢综合征无排卵患者的一线治疗药物。
