Drakatos Panagis, Leschziner Guy
Sleep Disorders Centre, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
King's College London, UK.
J Clin Sleep Med. 2016 Mar;12(3):449-50. doi: 10.5664/jcsm.5604.
Patients with narcolepsy usually develop excessive daytime sleepiness (EDS) before or coincide with the occurrence of cataplexy, with the latter most commonly associated with low cerebrospinal fluid (CSF) hypocretin-1 levels. Cataplexy preceding the development of other features of narcolepsy is a rare phenomenon. We describe a case of isolated cataplexy in the context of two non-diagnostic multiple sleep latency tests and normal CSF-hypocretin-1 levels (217 pg/mL) who gradually developed EDS and low CSF-hypocretin-1 (< 110 pg/mL).
发作性睡病患者通常在猝倒发作之前或与之同时出现日间过度嗜睡（EDS），后者最常与脑脊液（CSF）中下丘脑分泌素-1水平降低有关。在发作性睡病的其他特征出现之前发生猝倒是一种罕见现象。我们描述了一例孤立性猝倒病例，该患者进行了两次非诊断性多次睡眠潜伏期试验，脑脊液下丘脑分泌素-1水平正常（217 pg/mL），随后逐渐出现日间过度嗜睡和脑脊液下丘脑分泌素-1水平降低（<110 pg/mL）。
