Matsushige T, Chen B, Ringelstein A, Umutlu L, Forsting M, Quick H H, Sure U, Wrede K H
From the Department of Neurosurgery (T.M., B.C., U.S., K.H.W.), University Hospital Essen, University Duisburg-Essen, Essen, Germany Department of Neurosurgery (T.M.), Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Erwin L. Hahn Institute for Magnetic Resonance Imaging (T.M., B.C., L.U., H.H.Q., K.H.W.), University Duisburg-Essen, Essen, Germany
From the Department of Neurosurgery (T.M., B.C., U.S., K.H.W.), University Hospital Essen, University Duisburg-Essen, Essen, Germany Erwin L. Hahn Institute for Magnetic Resonance Imaging (T.M., B.C., L.U., H.H.Q., K.H.W.), University Duisburg-Essen, Essen, Germany.
AJNR Am J Neuroradiol. 2016 Apr;37(4):636-41. doi: 10.3174/ajnr.A4569. Epub 2015 Nov 12.
Giant intracranial aneurysms are rare vascular pathologies associated with high morbidity and mortality. The purpose of this in vivo study was to assess giant intracranial aneurysms and their wall microstructure by 7T MR imaging, previously only visualized in histopathologic examinations. Seven giant intracranial aneurysms were evaluated, and 2 aneurysms were available for histopathologic examination. Six of 7 (85.7%) showed intraluminal thrombus of various sizes. Aneurysm walls were depicted as hypointense in TOF-MRA and SWI sequences with excellent contrast ratios to adjacent brain parenchyma (range, 0.01-0.60 and 0.58-0.96, respectively). The triple-layered microstructure of the aneurysm walls was visualized in all aneurysms in TOF-MRA and SWI. This could be related to iron deposition in the wall, similar to the findings in 2 available histopathologic specimens. In vivo 7T TOF-MRA and SWI can delineate the aneurysm wall and the triple-layered wall microstructure in giant intracranial aneurysms.
巨大颅内动脉瘤是一种罕见的血管病变，具有较高的发病率和死亡率。本体内研究的目的是通过7T磁共振成像评估巨大颅内动脉瘤及其壁微观结构，此前这些结构仅在组织病理学检查中可见。对7个巨大颅内动脉瘤进行了评估，其中2个动脉瘤可进行组织病理学检查。7个中有6个（85.7%）显示出不同大小的腔内血栓。在TOF-MRA和SWI序列中，动脉瘤壁表现为低信号，与相邻脑实质的对比度极佳（范围分别为0.01 - 0.60和0.58 - 0.96）。在TOF-MRA和SWI中，所有动脉瘤的壁均可见三层微观结构。这可能与壁内铁沉积有关，类似于2个可用组织病理学标本中的发现。活体7T TOF-MRA和SWI能够描绘巨大颅内动脉瘤的瘤壁和三层壁微观结构。
