Chan M K, Lau N
Department of Medicine, University of Hong Kong, Queen Mary Hospital.
Int J Artif Organs. 1989 Apr;12(4):223-8.
The optimal number of times a hollow-fibre cuprammonium rayon (Terumo TAF) dialyzer could be used was determined in twelve patients. Each dialyzer was reused six times. There was a highly significant decrease in neutrophil count (46.9 +/- 6.9%, mean +/- s.e.m.), platelet count (9.6 +/- 3.8%, mean +/- s.e.m.) and serum C3 concentration (10.25 +/- 2.4%, mean +/- s.e.m.) 30 minutes after the commencement of dialysis The intensity of these changes decreased with the re-use of the dialyzers up to the fourth time. There was a small, but significant increase in serum beta 2-microglobulin concentrations after a 6-hour dialysis. The difference between pre- and post-dialysis serum beta 2-microglobulin concentrations appeared to be greater during the 5th and the 6th use (18.8% and 20.5% vs 5.0% during the first use). The clearance rates of urea and creatinine showed a trend to decrease from the fourth use onwards and the ultrafiltration coefficient was significantly reduced from the third use (8.5 +/- 4.0 mean +/- s.e.m.) onwards so that at the sixth use it was only 75.8 +/- 4.8%, (mean +/- s.e.m.) of the value at the first use. It is concluded that the optimal number of uses a cuprammonium rayon hollow-fibre dialyzer can be put to is four.
在12名患者中确定了中空纤维铜氨人造丝（泰尔茂TAF）透析器的最佳使用次数。每个透析器重复使用6次。透析开始30分钟后，中性粒细胞计数（46.9 +/- 6.9%，平均值 +/- 标准误）、血小板计数（9.6 +/- 3.8%，平均值 +/- 标准误）和血清C3浓度（10.25 +/- 2.4%，平均值 +/- 标准误）均有极显著下降。这些变化的强度随着透析器重复使用至第四次而降低。6小时透析后血清β2-微球蛋白浓度有小幅但显著的升高。在第五次和第六次使用期间，透析前和透析后血清β2-微球蛋白浓度的差异似乎更大（分别为18.8%和20.5%，而第一次使用时为5.0%）。尿素和肌酐的清除率从第四次使用起呈下降趋势，超滤系数从第三次使用（8.5 +/- 4.0，平均值 +/- 标准误）起显著降低，因此在第六次使用时仅为第一次使用时数值的75.8 +/- 4.8%（平均值 +/- 标准误）。结论是铜氨人造丝中空纤维透析器的最佳使用次数为四次。
