Bolle T, Meyer F, Walcher F, Lohmann C, Jockenhövel S, Gries T, Hoffmann W
Lehr- und Forschungsgebiet Tissue Engineering & Textile Implants, Institut für Textiltechnik, RWTH Aachen, Deutschland.
Universitätsklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Medizinische Fakultät der Otto-von-Guericke-Universität Magdeburg, Deutschland.
Zentralbl Chir. 2017 Apr;142(2):216-225. doi: 10.1055/s-0035-1558118. Epub 2015 Nov 13.
Biomaterials play a major role in interventional medicine and surgery. However, the development of biomaterials is still in its early phases in spite of the huge progress made within the last decades. On the one hand, this is because our knowledge of the molecular and cellular processes associated with biomaterials is still increasing exponentially. On the other hand, a wide variety of advanced materials with highly interesting properties is being developed currently. This review provides a short introduction into the variety of materials in use as well as their application in interventional medicine and surgery. Also the importance of biomaterials for tissue engineering in the field of regenerative medicine and the functionalisation of biomaterials, including sterilisation methods are discussed. For the future, an even broader interdisciplinary scientific collaboration is necessary in order to develop novel biomaterials and facilitate their translation into clinical practice.
生物材料在介入医学和外科手术中发挥着重要作用。然而,尽管在过去几十年里取得了巨大进展,但生物材料的发展仍处于早期阶段。一方面,这是因为我们对与生物材料相关的分子和细胞过程的了解仍在呈指数级增长。另一方面,目前正在开发各种具有高度有趣特性的先进材料。本综述简要介绍了正在使用的各种材料及其在介入医学和外科手术中的应用。还讨论了生物材料在再生医学领域对组织工程的重要性以及生物材料的功能化,包括灭菌方法。展望未来,为了开发新型生物材料并促进其转化为临床实践,需要更广泛的跨学科科学合作。