Karakosta Maria, Delicha Eumorfia-Maria, Kouraklis Gregory, Manola Kalliopi N
a Laboratory of Health Physics, Radiobiology and Cytogenetics, National Center for Scientific Research (NCSR) "Demokritos," Athens , Greece.
b Second Department of Propedeutic Surgery , School of Medicine, University of Athens, General Hospital "Laiko," Athens , Greece.
Arch Environ Occup Health. 2016 Nov;71(6):317-329. doi: 10.1080/19338244.2015.1116429. Epub 2015 Nov 13.
This study aimed to investigate whether occupational and environmental exposures, lifestyle, family, and medical history are associated with chronic lymphocytic leukemia (CLL) risk and its chromosomal abnormalities. The study included 138 CLL cases and 141 age- and sex-matched controls. Information data were collected through in-person interviews from cases and controls. Cytogenetic analysis was performed on CLL bone marrow cells. Positive associations were found between CLL and cancer family history, smoking, pneumonia, and exposure to petroleum, metals, pesticides/chemical fertilizers, detergents, and medical radiation. Chromosome deletions of 11q and 13q were more frequent in patients exposed to pesticides and rubber, respectively. This study investigated for the first time specific risk factors in relation to CLL aberrations and presented positive correlations. Moreover, it indicates the possible involvement of specific occupational and lifestyle risk factors in the onset of CLL.
本研究旨在调查职业和环境暴露、生活方式、家族史和病史是否与慢性淋巴细胞白血病（CLL）风险及其染色体异常相关。该研究纳入了138例CLL病例和141例年龄及性别匹配的对照。通过对病例和对照进行面对面访谈收集信息数据。对CLL骨髓细胞进行细胞遗传学分析。发现CLL与癌症家族史、吸烟、肺炎以及接触石油、金属、农药/化肥、洗涤剂和医疗辐射之间存在正相关。11q和13q染色体缺失分别在接触农药和橡胶的患者中更为常见。本研究首次调查了与CLL畸变相关的特定风险因素，并呈现出正相关。此外，它表明特定的职业和生活方式风险因素可能参与了CLL的发病过程。
