Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
PLoS One. 2024 Aug 27;19(8):e0307444. doi: 10.1371/journal.pone.0307444. eCollection 2024.
This study aimed to perform a systematic review and meta-analysis to investigate the relationship between wood dust exposure and leukemia. The objectives included synthesizing available evidence, assessing its quality, identifying potential sources of heterogeneity, and drawing conclusions regarding the association between wood dust and leukemia.
A systematic literature search was conducted to identify studies meeting that report on the association between wood dust and leukemia. The Joanna Briggs Institute Critical Appraisal tools were employed to ensure robust quality assessment. Meta-analysis, using random-effects models, synthesized evidence from studies with low risk of bias. Overall odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Subgroup analyses explored potential sources of heterogeneity.
The meta-analysis included a comprehensive review of various study types, encompassing 7 studies that examined the association between wood dust exposure and leukemia risk. The analysis revealed a statistically significant positive association, with an overall odds ratio (OR) of 1.56 (95% CI: 1.15-2.12). This indicates that individuals exposed to wood dust are 1.56 times more likely to develop leukemia compared to those not exposed, with the 95% confidence interval ranging from 1.15 to 2.12, highlighting a substantial risk elevation across different study designs. Quality assessment using The Joanna Briggs Institute Critical Appraisal tools demonstrated a low risk of bias across all included studies, enhancing the credibility of the observed association. Subgroup analyses were conducted to explore potential sources of heterogeneity within the studies. Notably, subgroup analysis based on the year of the study revealed significant differences, as indicated by an I^2 value of 87%. The robustness of these results underscores the importance of addressing wood dust exposure as an occupational hazard, particularly in industries related to woodworking and forestry.
This meta-analysis provides robust evidence supporting an increased risk of leukemia associated with wood dust exposure implying proactive measures in people exposed to dust.
本研究旨在进行系统回顾和荟萃分析，以调查木尘暴露与白血病之间的关系。目的包括综合现有证据，评估其质量，确定异质性的潜在来源，并得出关于木尘与白血病之间关联的结论。
系统地检索文献，以确定报告木尘与白血病之间关联的研究。采用 Joanna Briggs 研究所的批判性评估工具确保了稳健的质量评估。使用随机效应模型对具有低偏倚风险的研究进行荟萃分析，综合证据。计算了总体比值比（OR）和 95％置信区间（CI）。亚组分析探讨了异质性的潜在来源。
荟萃分析综合了各种研究类型的全面审查，包括 7 项研究，这些研究检查了木尘暴露与白血病风险之间的关联。分析显示，存在统计学上显著的正相关，总体比值比（OR）为 1.56（95％CI：1.15-2.12）。这表明，与未暴露于木尘的人相比，暴露于木尘的人患白血病的风险高 1.56 倍，95％置信区间范围为 1.15 至 2.12，突出了不同研究设计中风险的显著升高。使用 Joanna Briggs 研究所的批判性评估工具进行的质量评估表明，所有纳入研究的偏倚风险均较低，增强了观察到的关联的可信度。进行了亚组分析，以探索研究内部异质性的潜在来源。值得注意的是，基于研究年份的亚组分析显示出显著差异，I^2 值为 87％。这些结果的稳健性突出表明，应积极采取措施，解决与木工和林业相关的行业中暴露于木尘的问题。
荟萃分析提供了强有力的证据，支持木尘暴露与白血病风险增加之间存在关联，这意味着应采取积极措施保护暴露于木尘的人群。
