基质金属蛋白酶与癫痫发生
Matrix metalloproteinases and epileptogenesis.
作者信息
Ikonomidou Chrysanthy
机构信息
Department of Neurology, University of Wisconsin, Madison, WI, 53705, USA.
出版信息
Mol Cell Pediatr. 2014 Dec;1(1):6. doi: 10.1186/s40348-014-0006-y. Epub 2014 Nov 4.
Abstract
Matrix metalloproteinases are vital drivers of synaptic remodeling in health and disease. It is suggested that at early stages of epileptogenesis, inhibition of matrix metalloproteinases may help ameliorate cell death, aberrant network rewiring, and neuroinflammation and prevent development of epilepsy.
摘要
基质金属蛋白酶是健康和疾病状态下突触重塑的重要驱动因素。有人提出，在癫痫发生的早期阶段，抑制基质金属蛋白酶可能有助于改善细胞死亡、异常的网络重塑和神经炎症，并预防癫痫的发展。
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