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2
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3
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Mol Immunol. 2019 Oct;114:123-132. doi: 10.1016/j.molimm.2019.07.017. Epub 2019 Jul 24.
4
High serum IgA/C3 ratio better predicts a diagnosis of IgA nephropathy among primary glomerular nephropathy patients with proteinuria ≤ 1 g/d: an observational cross-sectional study.高血清 IgA/C3 比值在蛋白尿≤1g/d 的原发性肾小球疾病患者中更能预测 IgA 肾病的诊断：一项观察性横断面研究。
BMC Nephrol. 2019 Apr 30;20(1):150. doi: 10.1186/s12882-019-1331-0.
5
Systemic Hypertension at High Altitude.高原地区的系统性高血压
Hypertension. 2018 Sep;72(3):567-578. doi: 10.1161/HYPERTENSIONAHA.118.11140.
6
Clinicopathological features of pediatric renal biopsies in the plateau regions of China.中国高原地区儿童肾活检的临床病理特征
J Int Med Res. 2018 Nov;46(11):4539-4546. doi: 10.1177/0300060518786908. Epub 2018 Jul 20.
7
Serum C3/C4 ratio is a novel predictor of renal prognosis in patients with IgA nephropathy: a retrospective study.血清 C3/C4 比值是 IgA 肾病患者肾脏预后的新预测因子：一项回顾性研究。
Immunol Res. 2018 Jun;66(3):381-391. doi: 10.1007/s12026-018-8995-6.
8
Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group.牛津 IgA 肾病分类 2016 年更新：IgA 肾病分类工作组的报告。
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9
[Burden of disease attributable to high- sodium diets in China, 2013].[2013年中国高钠饮食所致疾病负担]
Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Sep 6;50(9):759-763. doi: 10.3760/cma.j.issn.0253-9624.2016.09.003.
10
Role of complement in IgA nephropathy.补体在IgA肾病中的作用。
J Nephrol. 2016 Feb;29(1):1-4. doi: 10.1007/s40620-015-0245-6. Epub 2015 Nov 13.

西藏地区 IgA 肾病患者的临床与病理特征。

The clinical and pathological characteristics of IgA nephropathy patients in Tibet.

机构信息

Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.

Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China.

出版信息

BMC Nephrol. 2022 Jul 27;23(1):269. doi: 10.1186/s12882-022-02895-4.

DOI:10.1186/s12882-022-02895-4
PMID:35896958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9327142/
Abstract

BACKGROUND

There are few studies on immunoglobulin A nephropathy (IgAN) at high altitude. This study aimed to analyze the clinical and pathological characteristics of IgAN between Tibet and Beijing, which provided a basis for improving diagnosis and treatment in Tibet.

METHOD

The clinical and pathological data of 80 patients from the People's Hospital of Tibet Autonomous Region (Tibetan group) and 991 patients from Peking University First Hospital (Beijing group) with IgAN proven by renal biopsy were compared retrospectively between January 2016 and July 2020. The kidney biopsy tissue was sent to the Department of Nephrology, Peking University First Hospital for pathological evaluation.

RESULTS

The proteinuria (2.9 [2.0, 4.9] vs. 1.1 [0.5, 2.4] g/day, P < 0.001) in the Tibetan group was significantly higher than that in the Beijing group. The serum albumin (30.4 ± 7.7 vs. 38.2 ± 5.5 g/L, P < 0.001) was significantly lower in the Tibetan group. The eGFR (77.7 ± 37.8 vs. 62.1 ± 33.6 ml/min/1.73 m, P = 0.001) was higher in the Tibetan group. The percentage of patients with nephrotic syndrome in the Tibetan group was significantly higher than that in the Beijing group (33.8% vs. 4.7%, P < 0.001).

CONCLUSION

There are differences in the clinical and pathological characteristics of IgAN between plateau and plain regions.

摘要

背景

高海拔地区关于免疫球蛋白 A 肾病（IgAN）的研究较少。本研究旨在分析西藏和北京地区 IgAN 的临床和病理特点，为提高西藏地区的诊治水平提供依据。

方法

回顾性分析 2016 年 1 月至 2020 年 7 月西藏自治区人民医院（西藏组）80 例和北京大学第一医院（北京组）991 例经肾活检证实的 IgAN 患者的临床和病理资料，肾活检组织由北京大学第一医院肾病科进行病理评估。

结果

西藏组蛋白尿（2.9 [2.0，4.9]比 1.1 [0.5，2.4] g/d，P<0.001）显著高于北京组，血清白蛋白（30.4 ± 7.7 比 38.2 ± 5.5 g/L，P<0.001）显著低于北京组，估算的肾小球滤过率（77.7 ± 37.8 比 62.1 ± 33.6 ml/min/1.73 m，P=0.001）显著高于北京组。西藏组肾病综合征患者比例显著高于北京组（33.8%比 4.7%，P<0.001）。

结论

高原和平原地区 IgAN 的临床和病理特点存在差异。