攻击供应链：HIV-1 限制丙氨酸摄取以防止 T 细胞激活。
Attacking the Supply Lines: HIV-1 Restricts Alanine Uptake to Prevent T Cell Activation.
机构信息
Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Montréal, QC H3T 1J4, Canada.
Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Montréal, QC H3T 1J4, Canada; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, QC H3T 1J4, Canada.
出版信息
Cell Host Microbe. 2015 Nov 11;18(5):514-7. doi: 10.1016/j.chom.2015.10.017.
HIV commonly escapes host antiviral immunity by downregulating cell-surface immunoreceptors. In a recent issue of Cell Host & Microbe, Matheson et al. (2015) systematically examined how HIV-1 infection remodels the T cell surface and identified serine carriers SERINC3/5 and alanine transporter SNAT1 as targets of HIV-1 Nef and Vpu, respectively.
HIV 通常通过下调细胞表面免疫受体来逃避宿主抗病毒免疫。在最近一期的《细胞宿主与微生物》杂志上，Matheson 等人（2015 年）系统地研究了 HIV-1 感染如何重塑 T 细胞表面，并分别鉴定出丝氨酸载体 SERINC3/5 和丙氨酸转运蛋白 SNAT1 为 HIV-1 Nef 和 Vpu 的靶点。
Zotero 插件