氨基酸及其转运体在 T 细胞免疫和癌症治疗中的作用。
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy.
机构信息
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Graduate Program in Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Graduate Program in Cancer Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
出版信息
Mol Cell. 2020 Nov 5;80(3):384-395. doi: 10.1016/j.molcel.2020.09.006. Epub 2020 Sep 29.
Metabolism reprogramming is critical for both cancer progression and effective immune responses in the tumor microenvironment. Amino acid metabolism in different cells and their cross-talk shape tumor immunity and therapy efficacy in patients with cancer. In this review, we focus on multiple amino acids and their transporters, solute carrier (SLC) members. We discuss their involvement in regulation of immune responses in the tumor microenvironment and assess their associations with cancer immunotherapy, chemotherapy, and radiation therapy, and we review their potential as targets for cancer therapy. We stress the necessity to understand individual amino acids and their transporters in different cell subsets, the molecular intersection between amino acid metabolism, and effective T cell immunity and its relevance in cancer therapies.
代谢重编程对于癌症的进展和肿瘤微环境中的有效免疫反应都至关重要。不同细胞中的氨基酸代谢及其相互作用塑造了肿瘤免疫和癌症患者的治疗效果。在这篇综述中，我们重点关注多种氨基酸及其转运蛋白、溶质载体 (SLC) 成员。我们讨论了它们在调节肿瘤微环境中的免疫反应中的作用，并评估了它们与癌症免疫疗法、化疗和放疗的关联，还回顾了它们作为癌症治疗靶点的潜力。我们强调了在不同细胞亚群中理解单个氨基酸及其转运蛋白、氨基酸代谢与有效 T 细胞免疫之间的分子交叉及其在癌症治疗中的相关性的必要性。
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