Etemadzadeh H, Meurman J H, Murtomaa H, Torkko H, Lappi L, Roos M
Department of Cariology, University of Helsinki, Finland.
J Clin Periodontol. 1989 Mar;16(3):175-8. doi: 10.1111/j.1600-051x.1989.tb01636.x.
Amine fluoride-stannous fluoride mouthrinse was tested in a double-blind cross-over clinical trial on 16 healthy subjects. Chlorhexidine mouthrinse prepared in the same colour and taste was used as the control. After a preparatory phase of 2 weeks, during which the subjects' plaque and gingival indices were reduced to zero by professional cleaning, 1-week test periods without mechanical cleaning were started in random order. The fluoride test solution did not prevent plaque accumulation and growth of salivary S. mutans and lactobacilli as did chlorhexidine. Furthermore, the plaque wet weight was statistically highly significantly greater during test periods of fluoride rinsing than during the chlorhexidine phase. The cleansing effect, as subjectively estimated by questionnaire, was in favour of chlorhexidine, but discolorations of teeth were assessed as significantly worse during chlorhexidine periods. Neither of the test solutions showed any effect on salivary flow rate, pH, buffering capacity, or lysosomal enzyme activity.
在一项针对16名健康受试者的双盲交叉临床试验中，对胺氟化物-氟化亚锡漱口水进行了测试。将制备成相同颜色和味道的洗必泰漱口水用作对照。在为期2周的准备阶段，通过专业清洁使受试者的牙菌斑和牙龈指数降至零，之后随机开始为期1周的无机械清洁测试期。与洗必泰不同，氟化物测试溶液不能防止牙菌斑积聚以及唾液中变形链球菌和乳酸杆菌的生长。此外，与洗必泰阶段相比，在使用氟化物漱口水的测试期内，牙菌斑湿重具有统计学意义上的显著增加。通过问卷调查主观评估，清洁效果有利于洗必泰，但在使用洗必泰期间牙齿变色情况被评估为明显更严重。两种测试溶液对唾液流速、pH值、缓冲能力或溶酶体酶活性均无任何影响。
